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This study focused on designing a niosome formulation that encapsulates pumpkin seed oil for topical use, achieving high entrapment efficiency and stability over three months.

This study reported that meloxicam-loaded spanlastics, created using the ethanol injection method, demonstrated potential as a drug delivery system with sustained release and effective entrapment efficiency.

This study found that massaging the skin significantly increases follicular penetration of liposomes in an ex vivo setting, while occlusion only enhanced penetration for rigid liposomes.

In this study, the researchers developed and optimized a bilayer tablet containing Tamsulosin and Finasteride, achieving sustained and immediate drug release with favorable release kinetics, including first-order and anomalous diffusion mechanisms, through in vitro testing.

In this study, researchers developed WS Biotin, a new water-soluble form of biotin, and found that it significantly improves water solubility compared to free biotin and enhances hair-related keratin expression, gene activity for hair growth in vitro, while also reducing melanin content in skin cells.

This study found that increasing the pH from 2.0 to 6.0 enhanced the binding of cationic solutes to hair keratin, driven primarily by hydrophobic and electrostatic interactions.

This study found that incorporating a block copolymer significantly alters the size and morphology of niosome drug delivery systems made of non-ionic surfactants and cholesterol, affecting their stability.

This study found that low frequency sonophoresis may reduce percutaneous absorption of sodium fluorescein-loaded liposomes by partially blocking follicular pathways in the skin.

Liposomes improve minoxidil delivery to hair follicles, enhancing treatment for hair loss.

This study found that solid lipid nanoparticles with minoxidil were as effective as commercial solutions for skin penetration and were non-corrosive, indicating potential for hair loss treatment.

This study evaluated niosome-based gels for delivering salicylic acid topically to treat acne vulgaris and found that the formulation SANG5, using Carbopol 940 and nutmeg oil, demonstrated the best drug release profile.

This review highlights how integrating medicinal chemistry with delivery science could transform the limitations of PROTACs—such as poor solubility and low cell permeability—into strengths, potentially advancing these compounds from experimental stages to clinical applications by optimizing their delivery and enhancing therapeutic efficacy.

This study aimed to develop a dermocosmetic exfoliating formulation using babassu fibers for androgenetic alopecia treatment, but found that although the formulation met sensory standards, it was unstable in sunlight and heat, suggesting a need for optimization before commercialization.

This study found that tea-seed saponin modified silicone polymer quaternary ammonium salt significantly improves hair conditioning performance in both dry and wet states when used in shampoo formulations.

Liposomes can make the antiandrogen RU 58841 more effective for skin application by reducing absorption, increasing skin retention, and targeting sebaceous structures.

This study found that ultrasonication pre-treatment at various power levels improved the color, protein solubility, and degree of hydrolysis of fish protein hydrolysates from mackerel side streams, and potentially reduced bitterness by decreasing hydrophobic free amino acids.

This review reports that cubosomes, used as drug nanocarriers in topical treatments, offer potential benefits for managing skin and eye diseases by improving bioadhesion, retention, and sustained release compared to conventional formulations, but also face manufacturing and biological challenges for effective clinical outcomes.

This study found that econazole nitrate delivered via MPEG-dihexPLA micelles significantly increased skin deposition compared to Pevaryl® cream, potentially enhancing drug bioavailability and clinical efficacy.

In this study, researchers optimized fast-dissolving tablets of nifedipine using a systematic approach, resulting in formulations that demonstrated rapid disintegration, enhanced dissolution profiles, and improved solubility, potentially improving oral delivery for patients requiring poorly soluble antihypertensive medication.

This review examines the promising role of nanocarriers, specifically liposomes and ethosomes, in enhancing transdermal drug delivery for skin diseases. Ethosomes, highlighted for their ability to penetrate deeper skin layers, show potential for more effective treatments but require further clinical investigation.

This study found that using 70% ethanol as a solvent for extracting unsoaked Leucaena leucocephala seeds produces a high extract yield while managing mimosine levels, indicating potential for nutraceutical use.

This study found that finasteride microemulsions significantly increased skin permeability in vitro, highlighting the potential for enhanced delivery of this drug through the skin.

In this study, researchers reported that hardshell capsules using the DiluCap® line of excipients demonstrated varying dissolution profiles under gastrointestinal-simulating conditions, with minoxidil and finasteride showing rapid release and melatonin and naltrexone displaying controlled release, indicating their suitability for different applications in compounding pharmacies.

This study found that niosomes significantly enhanced the skin deposition of retinoic acid while reducing its permeation, outperforming other tested nanoformulations.

This study found that using Labrasol® in phospholipid vesicle formulations improved minoxidil's skin delivery and local accumulation, showing potential for treating hair growth disorders.

In this study, brief ultrasound exposure reduced the follicular contribution to hydrocortisone absorption while significantly increasing total skin permeability, likely due to removal of the upper stratum corneum.

This study found that a shampoo containing quaternized wheat protein hydrolysate can effectively improve hair recovery by smoothing and compacting damaged hair surfaces, thanks to modifications that enhance protein adherence and disulfide bond formation at pH levels typical in hair care products.

This review discusses the potential use of liposomal formulations to enhance the effectiveness of cosmeceutical delivery through the skin barrier, with no new clinical results reported.

This study found that finasteride's solubility and bioavailability were improved when using a dimethyl-β-cyclodextrin inclusion complex compared to the drug alone.