The Formulation and In-Vitro Evaluation of WS Biotin, a Novel Encapsulated Form of D-Biotin with Improved Water Solubility for Hair and Skin Treatment Applications

    October 2023 in “ International Journal of Cosmetic Science ”
    Serena Duchi, Paloma Rebollo Torregrosa, Akram Hajuj … Alejandro Pérez‐Fernández
    Studysummary In this study, researchers developed WS Biotin, a new water-soluble form of biotin, and found that it significantly improves water solubility compared to free biotin and enhances hair-related keratin expression, gene activity for hair growth in vitro, while also reducing melanin content in skin cells.
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    Research cited in this study 10

    1. Staphylococcus Epidermidis Cicaria, a Novel Strain Derived From the Human Microbiome, and Its Efficacy as a Treatment for Hair Loss Molecules/Molecules online/Molecules annual · 2022
    2. Efficacy of Intramuscular Injections of Biotin and Dexpanthenol in the Treatment of Diffuse Hair Loss: A Randomized, Double-Blind Controlled Study Comparing Two Brands Dermatologic Therapy · 2022
    3. The Glypican-1/HGF/C-Met and Glypican-1/VEGF/VEGFR2 Ternary Complexes Regulate Hair Follicle Angiogenesis Frontiers in cell and developmental biology · 2021
    4. Rethinking Biotin Therapy for Hair, Nail, and Skin Disorders Journal of the American Academy of Dermatology · 2018
    5. Mutations in the Keratin 85 (KRT85/hHb5) Gene Underlie Pure Hair and Nail Ectodermal Dysplasia ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2009
    6. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    7. Hair Follicle-Specific Keratins And Their Diseases Experimental cell research · 2007
    8. Novel Type I Hair Keratins K39 And K40 Are The Last To Be Expressed In Differentiation Of The Hair: Completion Of The Human Hair Keratin Catalog Journal of Investigative Dermatology · 2007
    9. Proliferation and Differentiation of Cultured Human Follicular Keratinocytes Are Not Influenced by Biotin Archives of Dermatological Research · 1996
    10. Organization and Expression of Hair Follicle Genes ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1993

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    1. Low Level of Maternal Biotin Intake Changes the Expression of Biotin Transporter in Dams and Fetuses in Mice 2014