TLDR WS Biotin, a new form of D-Biotin, improves water solubility and shows potential for hair and skin care without being toxic at low levels.
The study developed and evaluated WS Biotin, a new encapsulated form of D-Biotin with 40 times improved water solubility, for use in hair and skin treatments. The microcapsules contained 46.1% D-Biotin and showed no significant cytotoxicity at concentrations below 0.1%. WS Biotin was found to promote follicular keratinocyte proliferation, enhance the expression of hair-associated keratins KRT40 and KRT85, and upregulate the expression of hair growth-related genes VEGF, FGF7, and IGF1, suggesting its potential in promoting hair maintenance and improving hair shaft strength. Additionally, WS Biotin demonstrated a potential skin-lightening effect by triggering a dose-dependent decrease in melanin levels. The study indicates the need for enhanced delivery strategies for biotin due to the high doses used.
3 citations,
August 2022 in “Molecules/Molecules online/Molecules annual” A new strain of bacteria from the human skin can help prevent hair loss.
1 citations,
July 2022 in “Dermatologic Therapy” Both brands of biotin and dexpanthenol injections improved hair loss, with Bayer also increasing the ratio of thick to thin hairs.
10 citations,
December 2021 in “Frontiers in cell and developmental biology” Glypican-1 is important for blood vessel growth in hair follicles and could help treat hair loss.
57 citations,
February 2018 in “Journal of the American Academy of Dermatology” Biotin supplements are not proven to improve hair or nails and may interfere with medical tests.
42 citations,
October 2009 in “The journal of investigative dermatology/Journal of investigative dermatology” Mutations in the KRT85 gene cause hair and nail problems.
759 citations,
February 2009 in “Current Biology” Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.
138 citations,
March 2007 in “Experimental cell research” Only a few hair-specific keratins are linked to inherited hair disorders.
28 citations,
July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”
13 citations,
January 2016 in “Journal of cosmetology & trichology” Alternative treatments show promise for hair growth beyond traditional methods.
6 citations,
November 2010 in “Histochemistry and cell biology” The proteins transthyretin and megalin are more present in the growth phase of hair, suggesting they might affect hair health and growth.
59 citations,
June 2008 in “Journal of The American Academy of Dermatology” The article explains the genetic causes and symptoms of various hair disorders and highlights the need for more research to find treatments.
August 2024 in “Applied Sciences” Plant extracts may help prevent or reverse hair graying.
1 citations,
March 2018 in “bioRxiv (Cold Spring Harbor Laboratory)” The hair treatment made hair grow faster and thicker and strengthened the hair roots.
