170 citations
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June 1974 in “BMJ” This study found that sodium valproate effectively stopped or reduced seizures in patients with various types of epilepsy, with best results in absence and myoclonic seizures, though it caused temporary hair loss in some cases.
169 citations
,
August 1981 in “BMJ” This study found that while sodium valproate improved seizure control in children with epilepsy, it often led to increased weight gain, with no severe side effects like liver disease or pancreatitis reported.
69 citations
,
March 2003 in “Journal of Experimental Botany” This study found that salinity stress in Arabidopsis thaliana root hairs may inhibit hair extension through changes in the tip-focused Ca(2+) gradient, while cytosolic pH remains unaffected.
59 citations
,
October 1976 in “BMJ” This case report observed that a child developed thrombocytopenia, characterized by a low platelet count and prolonged bleeding time, while on sodium valproate monotherapy for seizures.
59 citations
,
October 1976 in “Acta Neurologica Scandinavica” This study found that sodium valproate significantly reduced seizure frequency by over 50% in about 70% of patients with generalized seizures but was less effective for partial seizures.
44 citations
,
December 1975 in “Developmental Medicine & Child Neurology” This study found that sodium valproate effectively controlled petit mal seizures in children resistant to other anticonvulsants but was less effective for other seizure types.
30 citations
,
June 2024 in “Scientific Reports” This study explored a keratin, sodium alginate, and carboxymethyl chitosan hydrogel modified with tannic acid and found it to have promising wound-healing qualities, including similar elasticity to human skin, antimicrobial and antioxidant properties, and effective water retention. These attributes suggest potential applications in biomedical engineering.
29 citations
,
March 1987 in “Therapeutic Drug Monitoring” This study found that venous blood ammonia levels, particularly in patients taking valproate combined with other antiepileptic drugs, were significantly elevated compared to those on valproate alone.
23 citations
,
August 1989 in “American Journal of Veterinary Research” In this study, high selenium diets from different sources caused weight and hair loss in pigs, with additional hoof and coronary band problems particularly in those fed sodium selenate.
21 citations
,
July 2015 in “International Journal of Nanomedicine” In this study, ultradeformable liposomes containing Tween 20 or terpenes increased phospholipid bilayer fluidity and enhanced skin penetration of sodium fluorescein, with terpenes improving hair follicle penetration.
19 citations
,
September 2020 in “Pharmaceutics” This study investigated a new formula called SV-loaded nanospanlastics for topical application to treat androgenic alopecia. It showed similar effectiveness to minoxidil lotion but with fewer adverse effects when used to enhance dermal delivery and efficacy of sodium valproate.
17 citations
,
January 2013 in “Indian Journal of Pharmacology” This case report highlights an interest in exploring the relationship between serum levels of sodium valproate and hair loss, though no case reports currently establish this link.
15 citations
,
January 1987 in “Electrophoresis” This study found that electrophoretic keratin typing of head hair can identify specific polypeptide patterns, suggesting potential applications in genetic and forensic investigations.
14 citations
,
September 2025 in “Gels” This review reports that sodium alginate-based hydrogels show promise in biomedical applications due to their biocompatibility and versatility, but challenges such as mechanical strength and stability remain, highlighting the need for continued research to facilitate their clinical transition.
13 citations
,
November 2017 in “Neurotoxicity research/Neurotoxicity resarch” This study found that sodium metabisulfite activates sodium channels and increases cellular excitability and excitotoxicity in both cardiomyocyte and neuron models, which exacerbates seizures and neuronal damage in rats.
11 citations
,
January 1987 in “Electrophoresis” This study found that keratin phenotypes were consistent across different types of hair from the same individual, allowing for successful keratin typing following ABH blood group determination.
9 citations
,
January 2022 in “Biology” This study concluded that male mice are more susceptible to valproic acid-induced autism spectrum disorder than female mice, with noticeable differences in brain histoarchitecture and receptor protein levels.
8 citations
,
December 2021 in “BMJ neurology open” This study on Alzheimer's patients found that chronic sodium selenate treatment (up to 23 months) was safe and well-tolerated, with most adverse events being mild, and suggested potential slowing of cognitive decline, though confirmation requires further controlled studies.
8 citations
,
October 2019 in “The Journal of surgical research/Journal of surgical research” This study demonstrated that sodium valproate accelerates skin healing and reduces necrosis in a rat model of skin flap potentially through mechanisms involving GABA and histone deacetylase pathways.
8 citations
,
April 2011 in “Surgery today” This study found that sodium zinc dihydrolipoylhistidinate reduced chemotherapy-induced hair loss in rats, suggesting its potential as a treatment for this side effect.
7 citations
,
February 2024 in “The Journal of Physiology” This study suggests that male sex and androgenic steroid use increase the risk of atrial arrhythmias in individuals with arrhythmogenic right ventricular cardiomyopathy, especially those with desmosomal gene mutations.
7 citations
,
January 2023 in “ACS Applied Materials & Interfaces” This study found that probiotic-functionalized silk fibroin/alginate scaffolds, loaded with Lactobacillus casei, promoted scarless wound healing and hair follicle regeneration in infected wounds in rats.
7 citations
,
March 2021 in “Biology” This study found that silk fibroin/sodium alginate scaffolds seeded with dermal papilla cells may accelerate skin repair and hair follicle regeneration in a rat model.
6 citations
,
July 2018 in “Steroids” This study found that testosterone significantly influenced the expression and function of certain ion transporters in the vas deferens, impacting fluid secretion and contributing to a suitable environment for male fertility.
6 citations
,
December 2015 in “International journal of nanomedicine” This study found that low-frequency sonophoresis significantly decreased the skin penetration of sodium fluorescein-loaded PEGylated liposomes with D-limonene and affected percutaneous absorption by partially plugging hair follicle orifices.
In this study conducted at Shafa Hospital, Kerman, Iran, 3.5% of patients using sodium valproate as an antiepileptic experienced hair loss and curling over ten years.
5 citations
,
August 2014 in “Pharmaceutical Development and Technology” In this study, the researchers reported that while both propylene glycol and sodium lauryl sulfate enhanced finasteride's skin deposition, ethanol was the only effective enhancer of finasteride's permeation through the skin.
4 citations
,
July 2019 in “Headache The Journal of Head and Face Pain” This study suggests that low alternating daily doses of sodium divalproate may be effective for migraine prevention, similarly to higher doses, but can still lead to modest weight gain.
4 citations
,
January 2010 in “Laboratory Animal Research” This study found that Na2SiO3 accelerated hair regrowth in mice, indicating potential for treating alopecia, though it did not significantly alter enzyme activity compared to distilled water.
4 citations
,
February 2001 in “PubMed” This case study reports a 6-year-old girl developing acquired progressive kinking hair syndrome, likely induced by sodium valproate, marking it as the first documented instance linked to this medication.