Dermatoprotective Effect of Moringa Oleifera Leaf Extract on Sodium Valproate-Induced Skin Damage in Rats

    July 2024 in “ Drug and Chemical Toxicology ”
    Gülsüm Elik, Şule Oktay, İsmet Burcu Türkyılmaz, Burçin Alev, Umar Faruk Magaji, Özlem Saçan, Refiye Yanardağ, Ayşen Yarat
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    TLDR Moringa oleifera leaf extract protects skin from damage caused by sodium valproate.
    The study investigated the protective effects of Moringa oleifera leaf extract against skin damage induced by sodium valproate in female rats. The rats were divided into control and experimental groups, with the experimental groups receiving either moringa extract, sodium valproate, or both for 15 days. The results showed that moringa extract increased antioxidant parameters like glutathione and total antioxidant capacity while reducing oxidative stress markers such as lipid peroxidation and reactive oxygen species. These findings suggest that Moringa oleifera has potential dermatoprotective properties against the side effects of sodium valproate. However, the study's limitations include the lack of blood parameter data and histological findings to further support these results.
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