Skin Deposition and Permeation of Finasteride In Vitro: Effects of Propylene Glycol, Ethanol, and Sodium Lauryl Sulfate

    August 2014 in “ Pharmaceutical Development and Technology ”
    Ekapol Limpongsa, Napaphak Jaipakdee, Thaned Pongjanyakul
    From the encyclopedia
    Finasteride →

    Frontline, gold standard treatment for combatting androgenic alopecia

    propylene glycol →
    Ethanol →
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    Studysummary In this study, the researchers reported that while both propylene glycol and sodium lauryl sulfate enhanced finasteride's skin deposition, ethanol was the only effective enhancer of finasteride's permeation through the skin. Our plain-language summary of this paper — not a Tressless recommendation.
    The study investigated the effects of propylene glycol, ethanol, and sodium lauryl sulfate on the skin deposition and permeation of finasteride, a drug used to treat hair loss. The results showed that the presence of propylene glycol and ethanol increased the skin deposition of finasteride, while sodium lauryl sulfate had no significant effect. However, the presence of all three compounds increased the permeation of finasteride through the skin. The study suggests that the use of propylene glycol and ethanol in topical finasteride formulations may enhance its effectiveness in treating hair loss.
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