TLDR A substance called sodium zinc dihydrolipoylhistidinate can significantly reduce hair loss caused by chemotherapy in rats.
In a pilot study from 2011 involving 40 Wistar rats, the α-lipoic acid derivative sodium zinc dihydrolipoylhistidinate (DHLHZn) was shown to significantly reduce chemotherapy-induced alopecia. The rats were divided into four groups of 10, with one group acting as a control and the other three receiving cytosine arabinoside (AraC) to induce alopecia and different concentrations of DHLHZn (0%, 0.5%, or 1%) applied topically. The study found that rats treated with AraC and 0% DHLHZn experienced complete hair loss, while those treated with 0.5% or 1% DHLHZn had significantly less hair loss. Histological analysis indicated that DHLHZn treatment reduced inflammatory cell infiltration in hair follicles caused by AraC. The study suggests that DHLHZn could be a potential therapeutic agent for chemotherapy-induced alopecia, but further research is needed to confirm its effectiveness and understand its mechanisms of action.
27 citations,
March 2008 in “Cell stress & chaperones” Localized heat or specific injections can prevent chemotherapy-induced hair loss without affecting cancer treatment.
97 citations,
September 2006 in “Pharmaceutical Research” No treatment fully prevents hair loss from chemotherapy yet.
53 citations,
October 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” Topical calcitriol-analogs can reduce hair loss caused by chemotherapy.
127 citations,
July 1996 in “Journal of The American Academy of Dermatology” Minoxidil shortens baldness from chemotherapy by 50.2 days without significant side effects.
August 2021 in “Pharmacy Today” The document's conclusion about hair loss cannot be determined.
June 2021 in “Elsevier eBooks” The document's conclusion cannot be summarized because it is not readable or understandable.
2 citations,
November 2018 in “Seminars in Cutaneous Medicine and Surgery” Combining different treatments works best for female hair loss.
The article concludes that understanding the causes of hair loss and using continuous treatments like minoxidil and finasteride can help manage it, despite potential side effects.
9 citations,
October 2012 in “Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology” Stopping the drug olanzapine can reverse hair loss caused by it.
54 citations,
September 2012 in “Dermatologic Clinics” Some medications can cause hair loss, but stopping the drug usually leads to recovery within 3 months.
