Testosterone Enhances Expression and Functional Activity of Epithelial Sodium Channel, Cystic Fibrosis Transmembrane Regulator, and Sodium Hydrogen Exchanger in Vas Deferens of Sex-Steroid Deficient Male Rats

July 2018 in “ Steroids ”

Norlisah Ramli, Nelli Giribabu, Naguib Salleh

testosterone epithelial sodium channel ENaC cystic fibrosis transmembrane regulator CFTR sodium hydrogen exchanger NHE vas deferens flutamide finasteride amiloride Cftr inh-172 ion transporters γ-ENaC NHE-1 NHE-4 NHE-2 NHE-3

TLDR Testosterone changes how certain channels work in male rat reproductive tracts, affecting fertility-related fluid balance.

The study investigated the effects of testosterone on the expression and functional activity of epithelial sodium channel (ENaC), cystic fibrosis transmembrane regulator (CFTR), and sodium hydrogen exchanger (NHE) in the vas deferens of sex-steroid deficient male rats. Testosterone treatment increased the secretion rate and concentrations of Cl− and Na+ while decreasing pH and HCO3− concentrations in the vas deferens fluid. These effects were counteracted by amiloride, Cftr inh-172, flutamide, and finasteride. The study concluded that testosterone enhances the expression of γ-ENaC, CFTR, and NHE isoforms in the vas deferens epithelium, indicating their crucial role in maintaining the fluid microenvironment necessary for male fertility.

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