Effects of Testosterone on Mean Arterial Pressure and Aquaporin Expressions in the Kidney of Orchidectomized Adult Male Sprague-Dawley Rats

January 2017 in “ Archives of biochemistry and biophysics ”

Su Yi Loh, Nelli Giribabu, Khadijeh Gholami, Naguib Salleh

testosterone finasteride flutamide AQP-1 AQP-2 AQP-3 AQP-4 AQP-6 AQP-7 androgen Propecia

TLDR Testosterone raises blood pressure and changes kidney protein levels.

The study investigated the effects of testosterone on mean arterial pressure (MAP) and the expression of various aquaporins (AQP-1, 2, 3, 4, 6, and 7) in the kidneys of orchidectomized adult male Sprague-Dawley rats. Testosterone treatment increased MAP and the levels of AQP-1, 2, 4, 6, and 7 proteins and mRNA, while decreasing AQP-3 levels. These effects were counteracted by flutamide and finasteride. The distribution of AQPs was specific to kidney regions, with AQP-1 and 7 in the proximal convoluted tubule and AQP-2, 3, 4, and 6 in the collecting ducts. The findings suggested that testosterone-induced increases in AQP expression could enhance water reabsorption, leading to higher blood pressure.

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