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In this pilot study, researchers isolated skin-derived precursor-like cells from human-induced pluripotent stem cell-derived skin organoids, revealing their potential for future hair regenerative applications by exhibiting self-renewal and key marker expression.

This study found that skin-derived precursor cells in mice can originate from both neural crest and somite lineages but show functional similarities regardless of their developmental origins.

This study found that papillary dermal fibroblast progenitors in newborn mouse skin can be isolated and cultured to generate male germline cell precursors, demonstrating their potential through differentiation into cells with meiotic capability.

This paper describes a protocol for isolating and culturing skin-derived precursors to potentially induce hair growth and regenerate hair follicles, but reports no new experimental findings.

In this study, researchers found that mouse hair follicles recruit Langerhans cells by secreting chemokines, acting as key portals for these cells in both mice and humans.

This review discusses various tissue engineering approaches for hair follicle regeneration and biomaterials used, emphasizing its potential despite current clinical challenges.

This review discusses the potential of stem cell-based therapies combined with artificial nerve grafts for improving recovery in animal models of severe peripheral nerve injury, highlighting the need for further research on their application to humans.

This review discusses the role of dermal papilla cells in hair follicle formation and their potential use in cell therapy for hair loss, but reports no new research findings.

In this study, baricitinib treatment improved the differentiation of skin-derived precursors into adipocytes for diseases like Hutchinson-Gilford progeria syndrome, suggesting potential benefits when combined with lonafarnib.

This study found that ectopic expression of the lymphoid-enhancer factor can induce K17 protein in the skin, suggesting a link between skin development and wound repair processes in mice.

This review discusses the generation of germ cell-like cells from skin-derived stem cells and reports no new results; the potential for these cells to produce viable progeny remains unclear.

This review explores the role of hair follicle dermal stem cells in skin regeneration and restorative therapies, but it reports no new experimental results.

This study developed a new protocol to efficiently produce skin dermal stem cells from human induced pluripotent stem cells, which may aid in treating various skin disorders.

In this study, nondermal-derived CD34+ cells from adult peripheral blood were found to enhance wound healing and contribute to hair follicle neogenesis and skin regeneration.

This study concluded that hair-derived stem cells from older donors may offer a promising alternative for autologous corneal endothelial replacement, potentially benefitting patients of various age groups.

In this study, using stirred-suspension bioreactors to expand dermal stem cells resulted in larger numbers, but had reduced efficiency in forming hair follicle structures compared to static culture conditions.

This study suggests that skin-derived precursors from Sox2(+) hair follicle dermal cells have the potential to function as dermal stem cells, supporting hair morphogenesis, dermal maintenance, and wound-healing.

This study demonstrated that cultured epidermal stem cells and skin-derived precursors can regenerate functional hair follicles and sebaceous glands in both mice and adult humans, suggesting potential for bioengineered skin substitutes.

This review examines the diversity and role of stem cells in the adult dermis, noting a lack of precise understanding about their hierarchy and relationship to dermal fibroblast subpopulations, and reports no new results.

This study found that platelet-derived growth factor signaling is crucial for maintaining the hair follicle dermal stem cell pool and supporting their regenerative capacity.

The study characterized the transcriptional changes in porcine SKP cells transitioning to fibroblast-like cells, indicating potential roles for specific signaling pathways in this cell fate transition.

This study found that a novel 3D in vitro culture condition improved stemness markers and proliferation potential in human dermal stem/progenitor cells compared to traditional 2D methods.

In this study, the RADA-PRG hydrogel enhanced SKP proliferation, survival, and gene expression, effectively supporting hair follicle regeneration in mice.

This review discusses strategies for regenerating cutaneous nerve function in burn patients and highlights the potential role of autologous skin-derived adult stem cells in improving sensory recovery, but reports no new experimental findings.

This study found that dermal fibroblast cultures, especially those with higher alpha-smooth muscle actin expression, can be used to produce skin-derived precursor cells, unlike human hair follicle dermal papilla cultures.

In this study, researchers used 3D bioprinting with skin stem cells and specific hydrogels to create artificial skin that successfully promoted complete wound healing and the regeneration of skin structures, including hair follicles and blood vessels, in mice.

This study found that engineered skin substitutes made with skin-derived precursors and epidermal stem cells can regenerate hair follicles after grafting into nude mice.

This study found that human iPSC-derived dermal papilla precursor cells can regenerate hair follicle structures, offering a potential new treatment approach for permanent alopecia.

This study found that mature adipocytes can dedifferentiate into fibroblast-like cells, driven by PDGF and TGFβ signaling, which may play a role in wound repair and fibrosis.

This study used integrated single-cell chromatin and transcriptomic analyses in developing mouse skin to uncover gene networks involved in skin lineage specification and identified Mef2c+ upper fibroblasts as potential precursors to certain muscle-like structures, with cross-species findings in human skin.