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In this study, researchers found that selectively disabling ribonucleotide excision repair in mouse epidermis caused DNA damage, skin inflammation, and led to skin cancer, suggesting a potential role for this repair mechanism in tumorigenesis.

This research found that a biodegradable fibrous membrane incorporating fibroblast-derived ECM accelerated wound healing and improved neovascularization in a mouse model.

In this study, researchers demonstrated that fibroblasts derived from human embryonic stem cells can be used to create tissue-engineered dermal substitutes, effectively repairing mouse skin wounds within 20 days, highlighting a promising method for clinical applications in skin repair.

This study found that selectively inactivating ribonucleotide excision repair in mouse epidermis leads to DNA damage, keratinocyte intraepithelial neoplasia, and squamous cell carcinoma, indicating a potential tumor-promoting mechanism related to compromised genome maintenance.

This study found that selective inactivation of ribonucleotide excision repair in mouse epidermis led to spontaneous DNA damage, skin inflammation, and the development of squamous cell carcinoma, suggesting potential implications for cancer development in humans.

This review discusses the role of collagen XVII in maintaining stem cell niches and its impact on skin aging and wound repair, without reporting new clinical results.

This review highlights the potential of genetically or metabolically engineered live biotherapeutic products (eLBPs) for skin repair and disease treatment but emphasizes that translating these innovations into practical clinical applications remains challenging, requiring further research and development.

This review synthesizes current advances in transcriptomics and RNA regulatory networks, alongside stem cell-derived skin organoid research, to propose a conceptual framework for understanding and potentially guiding regenerative skin repair, without claiming clinical readiness.

This review discusses current advancements in mesenchymal stem cell-based therapies for skin repair and rejuvenation, focusing on therapeutic strategies, particularly highlighting the potential of neonatal and placenta-derived MSCs, and reports no new clinical results.

This study found that adipose-derived stem cell-conditioned media improved skin flap survival following ischemia/reperfusion injury in mice by increasing cell proliferation and the number of hair follicles, mediated by IL-6.

In a rat skin wound model, this study observed that a composite dressing using chitosan hydrogel and exosomes derived from adipose mesenchymal stem cells enhanced wound healing by promoting collagen deposition, angiogenesis, and regeneration of hair follicle structures.

This study identified a crucial role for epidermal Pgc-1α in regulating NAD+ signaling and influencing skin repair, with its dysfunction contributing to age-related wound healing defects.

This study demonstrated that a novel hydrogel combining extracellular vesicles from chemically induced mammary epithelial cells with chitosan significantly enhanced skin wound healing in a rat model.

Targeting THY1 can improve skin repair and healing.

This study suggests that PDCD4 regulates keratinocyte proliferation and contact inhibition, playing a role in epidermal homeostasis and wound healing.

This study found that in mice, dermal adipocytes initiate inflammation and aid repair after skin injury by releasing lipids, suggesting a role in managing inflammatory diseases and impaired wound healing.

This study concludes that fetal skin cells can significantly enhance wound healing and reduce scarring when used to treat severe burns and various wounds in children.

This review discusses the potential use of cultured primary fetal cells from a single organ donation to produce therapeutic products, emphasizing the need for process consistency and safety verification, but reports no clinical results.

This review addresses the role of skin-resident adult stem/progenitor cells in skin homeostasis, disease, and cancer development, and reports no new research results.

This chapter discusses the skin stem cell niche as a complex ecosystem and highlights the diverse components and interactions that influence stem cell function, but it reports no new experimental results.

This review discusses the role of extracellular vesicles from specific skin cells in wound healing, emphasizing their potential in regenerative medicine and reporting no new experimental results.

This systematic review synthesizes evidence from the past 20 years to highlight the potential of exosome-based therapies from stem cells and plants in improving cutaneous repair, skin aging, and challenging dermatological conditions through mechanisms like immunomodulation and collagen remodeling.

This study in SPF lambs found that primary and secondary orf virus infections trigger similar skin responses, but the primary infection caused a more severe and prolonged reaction.

This review discusses the roles of peripheral nerves in stem cell and immune responses within the skin and hematopoietic system, emphasizing their potential in developing new therapies; it reports no new experimental results.

In this review, researchers discuss how mitochondria-targeted biophysical priming of autologous biologics, through methods like photobiomodulation and ultrasound, can potentially enhance skin rejuvenation and wound repair by modulating mitochondrial function in skin cells.

This review outlines recent advances in using stem cells for skin repair and regeneration, suggesting potential for complete skin and appendage regeneration after severe burns, but presents no new clinical findings.

This article reviews the roles and mechanisms of stem and progenitor cell migration in adult organs for tissue homeostasis and regenerative medicine, but reports no new experimental results.

This study demonstrated that stem cells from the small intestine can differentiate into skin cells and reduce skin damage in irradiated mice, supporting the theory of stem cell plasticity.

This review examines the recent progress in using bioactive molecules for skin regenerative medicine and reports no new clinical results; the authors suggest this method could become a promising strategy for in situ skin regeneration.