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This perspective reviews enzyme-instructed self-assembly (EISA) as a conceptual framework for supramolecular chemical biology, emphasizing its innovative role in developing adaptive biomaterials and synthetic cellular machines without providing new experimental results.

In this study, the RADA-PRG hydrogel enhanced SKP proliferation, survival, and gene expression, effectively supporting hair follicle regeneration in mice.

In this study, researchers developed a self-assembling hydrogel called RADA-PDGF2 and found it to accelerate wound closure in a mouse model due to its pro-proliferative and pro-migratory properties, without causing cytotoxicity or immunogenicity.

RADA16-I can effectively deliver and release mangiferin, improving its solubility and bioavailability.

In a murine model of androgenetic alopecia, this study found that the newly designed IGF-1 biomimetic peptide Ac-GFFY-IGF led to faster and superior hair regrowth compared to minoxidil, suggesting potential for improved human therapies.

This study reported that newly developed RADA16-I peptide hybrids, with active motifs like GHK and KGHK, demonstrated improved wound healing in a mouse skin injury model without cytotoxicity, suggesting they might be effective scaffolds for tissue engineering and regeneration.

This study found that incorporating PCL-based nanoscaffolds into liver spheroids enhances their viability and liver-specific biofunctionality, suggesting these scaffolds improve the model's potential for preclinical drug screening by increasing sensitivity to acetaminophen toxicity compared to traditional methods.

This review assesses the benefits and limitations of various supramolecular hydrogels, including polymeric and peptide-based types, for wound healing, but reports no new clinical results.

In this study, researchers found that supramolecular peptide self-assembling materials derived from Pacific oysters exhibit promising effects for skin wound healing in vitro and in vivo, demonstrating procoagulant, antioxidant, anti-inflammatory, and regenerative properties that suggest potential as a natural treatment option.

In this study, researchers found that a scallop adhesive protein (Sbp9 Δ) forms strong adhesive coatings via disulfide-sticker strategies, which also promote hair regeneration in mouse models by activating Wnt signaling and enhancing angiogenesis, proving more effective than minoxidil for androgenetic alopecia.

This Ph.D. project aims to evaluate the self-assembling potential of hair keratin extracts and study the cellular response to both crude and purified keratins, highlighting their potential applications from biomedical to water remediation.

This review discusses recent advancements and ongoing challenges in engineering human skin with appendages using scaffold-free and scaffold-based bioengineering approaches, but it reports no new clinical results.

This review discusses recent advancements in the assembly and potential applications of gold nanoclusters, but presents no new experimental results; the authors highlight the need for further exploration in this area.

This study investigated a nanostructured system using PS-b-PAA diblock copolymer for incorporating the hydrophobic photosensitizer ClAlPc, finding it effective in causing cellular damage in Caco-2 cells under light while demonstrating no cytotoxicity without light, suggesting its potential use in photodynamic therapy.

This article reviews self-assembled nanoparticles, highlighting their promising role in drug delivery systems but noting the need for further research on stability and large-scale industrial application; it reports no new clinical findings.

This study found that oral administration of naturally safe active polypeptides from marine shellfish promoted scarless dermal wound healing in mice, potentially via effects on inflammation, fibroblast activity, and the "skin-gut" axis.

This article reviews the potential of bionanomaterials, derived from natural biomolecules, for wound healing and reports no new clinical results; it emphasizes the need for further research in this area.

This review highlights the potential of peptide-based PROTACs (pPROTACs) in expanding the target range of protein degraders beyond small-molecule limitations, particularly for undruggable proteins, by utilizing advances in design, conjugation, and bioPROTAC technology.

In this study, researchers demonstrated that human hair keratins can self-assemble into stable nanofibrous networks in vitro, which are compatible with human skin cells and useful for regenerative applications.

This review highlights recent advancements in using nanotechnology to improve the function and delivery of PROTAC drugs, despite existing challenges like low solubility and poor permeability, aiming to enhance their potential in disease treatment.

Nanocarriers could improve how drugs are delivered through the skin but require more research to overcome challenges and ensure safety.

This review discusses recent advances in hair regeneration therapies, highlighting the potential of nanotechnology and pluripotent stem cells, and reports no new results, emphasizing the need for further research.

This study reported that a novel nanomedicine combining berberine and sinapic acid significantly inhibited the growth of mouse mammary carcinoma cells and demonstrated an anti-tumor effect in vivo, without significant systemic toxicity after 28 days, suggesting a promising, low-toxicity therapeutic strategy for breast cancer.

This review summarizes the current applications and mechanisms of self-assembled peptide hydrogels in promoting skin, bone, and nerve regeneration, highlighting their potential due to their biocompatibility and supportive role in tissue healing.

This review discusses the unique properties, design, and fabrication of peptide hydrogels for biomedical applications, focusing on advances in drug delivery, gene therapy, and regenerative medicine; it reports no new clinical results.

This review outlines how combining biomembrane-based nanostructures and microstructures with hydrogels can enhance strategies for chronic wound healing, by utilizing the unique properties of both to address metabolic disturbances and severe symptoms in wound care.

This review examines new formulations for delivering 5-α-reductase inhibitors to improve targeted drug delivery in androgenetic alopecia, but reports no new clinical results.

This review discusses how polymer- and lipid-based nanostructures can enhance wound healing by addressing issues like microbial contamination and inflammation, though it reports no new clinical results.

This review discusses the mechanisms involved in wound healing and explores the potential of nanomaterials as a promising approach to managing chronic wounds, but reports no new clinical findings.

This review highlights recent advances in chitosan-based nanoparticles (CS NPs) for drug delivery, discussing their modifications, preparation methods, production with organic and inorganic materials, and their latest implementations in the field, emphasizing the role of CS NPs in improving drug transport and release properties.