Enzyme-Instructed Self-Assembly for Cellular Supramolecular Chemistry

    November 2025 in “ Chemistry - An Asian Journal ”
    Yali Huang, Xingjie Hu, Zhongxi Yang, Bing Xu
    TLDR EISA uses enzymes to create precise nanostructures in cells, offering new ways to design adaptive materials and therapies.
    The document discusses Enzyme-Instructed Self-Assembly (EISA) as a promising method for creating supramolecular structures with applications in cancer therapy, drug delivery, and biomaterial development. EISA leverages enzymatic reactions to convert soluble precursors into self-assembling nanostructures, offering advantages like enhanced selectivity and reversible modulation of cellular functions. It is particularly effective in tumor environments, where it can suppress growth or induce cell death by forming functional intracellular structures. The study highlights EISA's potential in therapeutic delivery, tissue engineering, and the development of growth factor-mimicking materials for hair regeneration and wound healing. Additionally, EISA's ability to generate artificial cellular nanostructures provides insights into enzyme activity in live cells, with future applications in disease treatment and biomedical research.
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