Peptide-Based PROTACs: Transitioning from Static Paradigm to a Dynamic Landscape in Targeted Protein Degradation
March 2026
in “
Bioconjugate Chemistry
”
Studysummary This review highlights the potential of peptide-based PROTACs (pPROTACs) in expanding the target range of protein degraders beyond small-molecule limitations, particularly for undruggable proteins, by utilizing advances in design, conjugation, and bioPROTAC technology.
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