Oral Delivery of Marine Shellfish Supramolecule Peptides for Skin Wound Healing

May 2022 in “ Colloids and Surfaces B: Biointerfaces ”

Faming Yang, Di Zhao, Kun Zhang, Zhouchi Wang, Yuxin Wang, Changcheng Wu, Shenghao Cui, Tingting Guo, Liqi Chen, Jingdi Chen

marine shellfish peptides Farrer's Scallop Azumapecten farreri Pacific oyster Crassostrea gigas animal protease controllable hydrolysis supramolecular material antioxidants procoagulants epidermal cell proliferation inflammatory responses wound healing scallop peptides oyster peptides APs AAPs CAPs

TLDR Eating peptides from certain shellfish may help wounds heal faster by reducing inflammation.

The study "Oral delivery of marine shellfish supramolecule peptides for skin wound healing" investigated the wound healing properties of peptides extracted from Farrer's Scallop (Azumapecten farreri) and Pacific oyster (Crassostrea gigas). The researchers used animal protease and controllable hydrolysis technology to obtain randomized self-assembling supramolecular material of peptides from these shellfish. The peptides, referred to as APs (AAPs and CAPs), were found to act as antioxidants, procoagulants, and promoters of epidermal cell proliferation. In vivo experiments showed that oral administration of these peptides effectively promoted wound healing by inhibiting inflammatory responses. This study suggests that marine-derived peptides could potentially be used in wound healing treatments.

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