Eco-Friendly Extraction and Formulation of Black Sea Shark Liver Oil-Based Emulgel for Anti-Inflammatory and Healing Dermatocosmetic Applications

    March 2025 in “ Gels ”
    Sorinel Marius Neacșu, Lucian Hîncu, Lavinia Vlaia, Dumitru Lupuliasa, Alexandru Scafa‐Udriște, Sebastian Mihai, Gabriel Olteanu, Alexandru Mihai Grumezescu, Răzvan Ene, R Marin, Magdalena Mititelu
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    Studysummary This study explored Black Sea shark liver oil-based emulgels, finding that the addition of borage oil (Gel 2) enhanced the anti-inflammatory and wound healing properties compared to shark liver oil alone (Gel 1) and a reference diclofenac gel, suggesting promising eco-friendly applications in dermatocosmetics. Our plain-language summary of this paper — not a Tressless recommendation.
    This study explores the eco-friendly extraction and formulation of emulgels using Black Sea shark liver oil, with and without borage oil, for anti-inflammatory and wound healing dermatocosmetic applications. Two formulations were tested on 60 male Wistar rats for anti-inflammatory effects and 40 for wound healing. Gel 2, containing both shark liver oil and borage oil, demonstrated superior performance in reducing edema and accelerating wound closure compared to Gel 1 and a reference product, Cicatrizin®. The study highlights the potential of these natural lipid-based emulgels as effective and sustainable alternatives for treating inflammatory skin conditions and promoting tissue regeneration.
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