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Skin aging is largely due to differences in stiffness and elasticity between skin layers, leading to wrinkles.

Hidradenitis suppurativa may be related to hormones and patients often have metabolic disorders; more research is needed to understand this connection.

Isotretinoin is safe and effective for acne, with common side effects like dry lips; serious side effects are rare.

Vitamin D3 analogs can promote hair growth in mice genetically prone to hair loss.

Male hormones affect oil-producing skin cells differently based on their body location, and the drug spironolactone can reduce these effects.

Gene therapy has potential as a future treatment for Hutchinson-Gilford progeria syndrome.

Plant-based ingredients are effective and safe for modern skincare products.

Tofacitinib temporarily regrew hair in a man with alopecia, but its effects didn't last.

Eating high glycemic foods and drinking milk may worsen acne by increasing insulin and IGF-1 levels.

Genetics play a role in acne, but how exactly they contribute is not fully understood.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Adrenal disorders can cause lasting brain and behavior issues in children.

The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.

Hair problems are common and distressing for women, but increasing knowledge of treatments offers hope.

Natural molecules like inositols, resveratrol, vitamins, and omega-3 fatty acids may help manage Polycystic Ovary Syndrome (PCOS), but their effects vary and need more exploration.

A substance called VIP might protect hair follicles from being attacked by the immune system, and problems with VIP signaling could lead to hair loss in alopecia areata.

Most pregnant women experience skin changes like darkening and stretch marks, and some may have skin conditions that usually get better after giving birth.

Fibroblasts, cells usually linked to tissue repair, also help regenerate various organs and their ability decreases with age. Turning adult fibroblasts back to a younger state could be a new treatment approach.

Existing drug dexamethasone may lower death risk in severe COVID-19 cases; more research needed for other drugs.

Hydrogen peroxide and monoethanolamine in hair dye can cause dermatitis and hair loss.

Activating Notch in adult skin causes T cells and neural crest cells to gather, leading to skin issues.

The document concludes that there is no agreed-upon best method for measuring drug delivery within hair follicles and more research is needed to validate current techniques.

Scientists created a long-lasting stem cell line from human hair that can turn into different skin and hair cell types.

Effervescent formulations may improve minoxidil delivery, increasing effectiveness and reducing applications needed.

Type I interferons play a key role in the development of various skin diseases.

Pannexin 3 is important for bone formation and the development of bone cells.

Extramammary Paget disease can spread deeply into tissues, reaching up to 3.6 mm.

Mice without certain skin proteins had abnormal skin and hair development.

Skin organoids are a promising new model for studying human skin development and testing treatments.

Patient-derived melanocytes can potentially treat vitiligo by restoring skin pigmentation.