Depth and Patterns of Adnexal Involvement in Primary Extramammary (Anogenital) Paget Disease: A Study of 178 Lesions From 146 Patients

    February 2016 in “ ˜The œAmerican journal of dermatopathology/American journal of dermatopathology ”
    Anastasia M. Konstantinova, К В Шелехова, Colin J.R. Stewart, Dominic V. Spagnolo, Heinz Kutzner, Denisa Kacerovská, Jose A. Plaza, Saul Suster, J Bouda, Michal Pavlovsky, Liubov Kyrpychova, Michal Michal, Emmanuella Guenova, Dmitry V. Kazakov
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    Studysummary This study observed that in primary extramammary Paget disease, carcinoma commonly spreads to significant depths along hair follicles and eccrine ducts, with a maximal depth of 3.6 mm. Our plain-language summary of this paper — not a Tressless recommendation.
    Extramammary Paget disease (EMPD) often involved adnexal structures, such as hair follicles and eccrine ducts, which facilitated deeper tissue spread. In a study of 178 lesions from 146 patients, the maximal depth of carcinomatous spread was 3.6 mm. This significant potential for deep spread should be considered when planning topical or novel local treatments for EMPD.
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