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This review article highlights recent advances in microneedle technology for wound healing and tissue regeneration, discussing various cargo types, structural designs, and fabrication methods, and suggesting guidelines for designing microneedle systems tailored to specific applications.

This study found that iron retention in macrophages impairs hair follicle growth and delays wound healing in mice, highlighting the importance of macrophage iron release for skin health.

This study reported significant upregulation and release of S100A4 in psoriatic skin, which may actively contribute to psoriasis pathogenesis.

This review explores how the interaction of AKT and β-catenin signaling pathways, alongside photobiomodulation effects on cellular signaling proteins, could potentially enhance diabetic wound healing by addressing dysregulated cellular signaling.

This review highlights recent advancements in using nanotechnology for scar prevention and treatment, emphasizing the unique properties of nanomaterials in drug delivery and the challenges that remain in maximizing their potential for effective scar interventions.

In this retrospective review, the author discusses key discoveries in understanding androgen excess disorders like PCOS, focusing on genetic and molecular insights gained from 1965 to 2015.

This review examines the dysregulation of innate immune barriers in the early stages of hidradenitis suppurativa and calls for further research on the role of the hair follicle and immune responses, but reports no new results.

This study found that hair follicles play a significant role in regulating skin barrier function, with disruptions in the upper hair follicle affecting the epidermis, influencing processes like desquamation and sebum release, and leading to cell movement into the epidermis.

This review discusses the role of transient receptor potential channels in pathological scarification and suggests these channels as potential targets for its prevention and treatment, although it reports no new clinical findings.

This study found that facial rejuvenation with fat grafting around the prejowl sulcus provided better improvement in jowling and had fewer adverse effects compared to mandibular ligament release without fat grafting.

This review discusses the increased incidence of hair loss and telogen effluvium among COVID-19 patients and evaluates existing evidence for regenerative treatments like PRP and HFSCs, finding limited published data.

In this study, researchers developed grooved microneedles made from hyaluronic acid for precise transdermal drug delivery, achieving accurate dosage with a high probability of delivery (98% or more) by using an easy-to-operate applicator for shearing force.

This review proposes a treatment protocol for androgenetic alopecia using platelet-rich plasma, but reports no new clinical results, highlighting the need for standardized preparation and assessment methods.

In this review, researchers reported that pyroptosis, a type of inflammatory cell death linked to inflammasome activity, is a key factor in the pathogenesis of alopecia areata and may present new therapeutic opportunities, though most treatments are still in early research stages.

This study found that synthetic RNA and DNA trigger significant increases in certain chemokines in human keratinocytes, predominantly via NF-κB activation, without evidence of alternative splicing, suggesting other regulatory pathways may be involved.

This study by Moore et al. (2025) provides the first evidence linking C-tactile afferents in humans to hair follicles, showing that these nerve fibers respond to hair movement rather than skin deformation, adding complexity to the understanding of their role in emotion and touch.

This critique of a 2019 study highlights the potential of a liposomal hydrogel for delivering Minoxidil and Tretinoin to treat androgenetic alopecia, but underscores the need for in vivo trials and further stability and interaction analysis to validate its promise.

This review summarizes existing knowledge on androgenetic alopecia, including its epidemiology, pathophysiology, and management, but presents no new research findings.

In this study, researchers observed that the YH complex, made from Astragalus membranaceus and Cinnamomum cassia, promoted hair regrowth and increased hair shaft thickness in mice, potentially through increased growth factors and Wnt/β-catenin signaling, suggesting its use for treating various forms of hair loss.

This study reviews current treatments for PCOS and evaluates Tirzepatide as a potential option for its management, suggesting possible benefits for those with obesity and metabolic syndrome but not for those of normal weight.

This review highlighted recent advances in nanocarrier-based topical delivery systems for skincare, emphasizing their potential to enhance ingredient stability, penetration, and targeted release while addressing specific pathophysiological skin concerns.

This review summarizes the current applications and mechanisms of self-assembled peptide hydrogels in promoting skin, bone, and nerve regeneration, highlighting their potential due to their biocompatibility and supportive role in tissue healing.

This review highlights the potential of microneedles for immunotherapy, emphasizing their ability to enhance immune responses and reduce side effects through precise and stimuli-responsive delivery, especially in tumor treatment, while also noting the limitations and areas for improvement in current systems.

This review discusses the design, properties, and potential applications of smart microneedles, with no new clinical results presented.

In this study, researchers developed a new self-administered finasteride delivery system using powder-carrying microneedles that improved hair growth efficacy and addressed safety concerns compared to topical finasteride gel by allowing sustained intradermal release of the drug for three days with a single application.

This review examines the potential of swellable microneedles in drug delivery and diagnostics, highlighting innovations and challenges in their use for chronic disease treatment, but noting that issues like physiological responsiveness and long-term stability still require research.

This review article highlights how hair follicle-targeting drug delivery systems enhance therapeutic outcomes and reduce side effects for treating conditions like androgenetic alopecia and acne vulgaris. The authors discuss current formulations and evaluate their performance in both preclinical and clinical settings.

This review discusses the use of inorganic-based biomaterials for hemostasis and wound healing, including various preparation methods and mechanisms, but reports no new clinical results.

This review highlights the potential of microneedles and nanomedicine in advancing tissue regeneration, emphasizing their innovative, localized, and minimally invasive approaches as promising solutions to current challenges in treating chronic wounds and degenerative diseases.

This review examines the use of microneedles for treating alopecia areata, highlighting their ability to enhance drug delivery through the skin by bypassing the outer barrier and promoting hair growth with minimal invasiveness.