The Search for the Causes of Common Hyperandrogenism, 1965 to Circa 2015

The document reviews the progress in understanding common hyperandrogenism from 1965 to 2015, focusing on polycystic ovary syndrome (PCOS) as a primary cause in women. It highlights significant discoveries, such as the role of the DENND1A gene variant and the impact of insulin resistance and obesity on symptom severity. The review emphasizes the complexity of PCOS, involving genetic, environmental, and endocrinological factors, and underscores the importance of early diagnosis and management. Despite advancements, further research is needed to fully understand these disorders and develop effective treatments.