A Review on an Evaluation of a Liposomal Hydrogel for Combined Minoxidil and Tretinoin Delivery in Androgenetic Alopecia

January 2025 in “ International journal of research and scientific innovation ”

Shailendra B. Patel, Shailendra B. Patel, Hamzah Moinuddin Momin, M Chaudhary

liposomal hydrogel minoxidil tretinoin androgenetic alopecia liposomes topical delivery drug stability dermal compatibility extended release Rogaine Retin-A

TLDR The liposomal hydrogel shows promise for hair loss treatment but needs more testing.

The review evaluates a 2019 study by Kochar et al. on a liposomal hydrogel designed for the combined topical delivery of Minoxidil and Tretinoin to treat androgenetic alopecia. The study presents a promising alternative to traditional treatments by using liposomes to enhance drug stability and dermal compatibility, with a hydrogel base for better application and extended release. However, the review identifies significant gaps, such as the lack of in vivo efficacy data, insufficient analysis of the interaction between the two drugs, and incomplete stability testing. It recommends further in vivo trials, advanced interaction analysis, and comprehensive stability protocols to validate the system's potential as a clinical treatment.

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