35 citations
,
August 2004 in “Epilepsy & behavior” In this study, divalproex sodium extended-release was found to be more tolerable and preferred by patients compared to the delayed-release formulation, with improved seizure control and psychiatric symptom relief.
13 citations
,
October 2010 in “Seizure” This study reported that extended-release valproate significantly reduced seizure frequency and improved quality of life in epilepsy patients over six months, despite some adverse effects like weight gain and tremor.
6 citations
,
August 2021 in “International Journal of Pharmaceutics” This study demonstrated that finasteride-loaded PLGA microspheres created using a novel microfluidic device exhibit extended drug release in beagle dogs, with modifications allowing for release up to 3 months.
July 2026 in “Journal of the American Academy of Dermatology” 16 citations
,
February 2009 in “Clinical neurology and neurosurgery” In this study, patients with epilepsy who switched from immediate-release to extended-release divalproex sodium did not experience significant changes in seizure frequency, but most preferred the new formulation due to a subjective decrease in tremor during daily activities.