Seizure Control and Side-Effect Profile After Switching Adult Epileptic Patients from Standard to Extended-Release Divalproex Sodium

    February 2009 in “ Clinical neurology and neurosurgery ”
    Serge J. C. Pierre-Louis, Richard T. Brannegan, Arthur T. Evans
    Studysummary In this study, patients with epilepsy who switched from immediate-release to extended-release divalproex sodium did not experience significant changes in seizure frequency, but most preferred the new formulation due to a subjective decrease in tremor during daily activities. Our plain-language summary of this paper — not a Tressless recommendation.
    The study evaluated 47 adult epilepsy patients who were switched from immediate-release to extended-release divalproex sodium and followed for 6 months. Results showed no significant change in seizure frequency or overall side-effect profile. However, patients reported a significant subjective improvement in tremor, as measured by a 25-item questionnaire, and 71% preferred the extended-release formulation. The study concluded that switching to extended-release divalproex sodium is safe and preferred by most patients, particularly due to the perceived reduction in tremor impact on daily activities.
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