Significance of the S100A4 Protein in Psoriasis

The study investigated the role of the S100A4 protein in psoriasis by comparing its expression in psoriatic skin to normal skin and found that S100A4 was significantly upregulated in the dermis of psoriatic skin. The research included biopsies from 11 patients with psoriasis and 4 healthy individuals, and used ELISA assays to measure S100A4 levels. In a human psoriasis xenograft SCID mouse model, treatment with S100A4 polyclonal antibodies led to a significant reduction in epidermal thickness, cell proliferation, and dermal vascularization, suggesting that S100A4 is involved in the pathogenesis of psoriasis. The study also noted increased p53 stabilization in the basal layer of the epidermis near cells expressing S100A4. The findings indicate that S100A4 could be a potential target for psoriasis therapy. The study involved a total of 13 patients with moderate to severe psoriasis and 8 healthy control subjects.