research Significance of the S100A4 Protein in Psoriasis
This study reported significant upregulation and release of S100A4 in psoriatic skin, which may actively contribute to psoriasis pathogenesis.
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5 / 1000+ resultsresearch Removing all obstacles: A critical role for p53 in promoting tissue renewal
This review discusses how the p53 tumor suppressor gene helps maintain adult tissue homeostasis by promoting the removal of DNA-damaged cells, with implications for treating age-related diseases and p53-deficient cancers; it reports no new results.
research Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner
This study found that transient mtDNA double strand breaks in mice accelerated aging in certain tissues through increased reactive oxygen species, independent of p21/p53 pathway mediation.
research The Paradox of p53: What, How, and Why?
The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.
research Epimorphic regeneration in mice is p53-independent
This study reports that in MRL mice, loss of p53 does not impair ear regeneration, suggesting p21's potential role in this process may involve the Tgfb/Smad pathway.
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