Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study observed that dissolving microneedles made from PVP-K90 and HPMC E50, incorporating Oryza sativa L. extract complex, showed enhanced transfollicular skin penetration and maintained safety for keratinocytes, with the P25H5 formulation demonstrating faster dissolution and greater effectiveness.

This study investigated the use of dissolving microneedle patches to improve the skin-lightening effects of alpha-arbutin and resveratrol, finding that the patches enhanced intradermal delivery and slightly decreased the melanin index without affecting skin hydration or causing irritation over 24 hours.

Hydrogel microneedles with special nanoparticles and growth factor improve hair growth better than minoxidil for hair loss treatment.

In this study, the authors developed a medicated face mask using electrospun fibers to deliver the active compound Eflornithine hydrochloride for managing hirsutism. The mask showed promising drug release characteristics, a high safety profile, and reduced hair growth in mice.

This review highlights how advanced nanocarrier and microneedle-based transdermal drug delivery strategies can potentially improve the treatment of skin diseases by enhancing site-specific drug delivery, increasing skin penetration, and reducing systemic toxicity compared to conventional methods.

This review summarizes the application of microneedles in treating various skin diseases and highlights challenges like low drug loading, noting no new clinical results are reported.

This study found that a ceria nanozyme-integrated microneedles patch accelerated hair regeneration in an androgenetic alopecia mouse model more effectively than minoxidil, with reduced application frequency and minimal skin damage.

In this study, researchers developed a dissolvable microneedle patch combining HA-TEMPO and Portulaca oleracea L.-derived nanoparticles, which effectively reduced oxidative stress and inflammation in an atopic dermatitis model while restoring immune balance, suggesting a promising treatment strategy.

This study found that the newly developed microarray patches for intradermal delivery of finasteride showed high drug content and significantly improved skin deposition compared to existing methods.

This study found that cubosomes combined with dissolving microneedles enhanced transdermal penetration and hair growth efficacy of beta-sitosterol for treating alopecia.

In this study, researchers developed microparticle-embedded gas-propelled microneedles that showed higher drug loading and transdermal delivery efficiency compared to traditional microneedles.

This study found that microneedle delivery of Polygonum multiflorum extract led to earlier pigmentation and hair regrowth in mice with androgenetic alopecia.

This review summarizes recent progress in microneedle-based drug delivery systems and discusses their potential impact on cellular mechanisms and immunization signaling pathways, highlighting the need for further development in fabrication methods.

This review discusses hydrogel-forming microneedles for non-invasive drug delivery in dermatology and reports no new clinical results, emphasizing their promise in improving treatment adherence and patient comfort.

This review examines various new approaches for treating dry eye disease, including biomaterials, regenerative therapy, and tissue engineering, and emphasizes the need for clinical efficacy studies to advance these therapies for human use.

In this study, a hydrogel with anti-inflammatory, antibacterial, antioxidant, and wound tissue adhesion properties was developed, showing significant potential for wound healing and suggesting it could offer a new and effective treatment option in clinical settings.

In this study, a microneedle patch containing conditioned media from hypoxia-pretreated stem cells enhanced hair regeneration in an androgenetic alopecia mouse model by boosting perifollicular vascularization and hair follicle stem cell activation compared to minoxidil.

This review discusses various microneedle technologies for long-acting drug delivery, highlighting design considerations and challenges in bringing these minimally invasive devices to market, but it reports no new clinical results.

This review highlights advancements in nanotechnology-based treatments for androgenetic alopecia, noting that these strategies could improve targeting and modulation of hair follicle environments compared to traditional therapies like minoxidil and finasteride, but also emphasizes challenges around safety, manufacturing, and regulation.

This study found that Dex-loaded hyaluronic acid hydrogel microneedles significantly reduced pain in an acute inflammatory visceral pain model without sedation, suggesting a promising and patient-friendly alternative to intravenous delivery.

This study found that using a stevioside-based microneedle patch significantly increased minoxidil's solubility and skin absorption, promoting hair growth in animal models and achieving 67.5% area coverage by day 35, highlighting the potential of this novel delivery system for androgenetic alopecia treatment.

This review highlights the potential of microneedle technology in traditional Chinese medicine as a promising transdermal delivery system for skin diseases, showcasing improved efficacy and reduced side effects of TCM ingredients while discussing the challenges of its clinical application.

This review summarizes advancements in biomedical engineering for hair follicle regeneration, highlighting strategies like cell transplantation and tissue engineering to reconstruct hair follicles, and discusses both their technical limitations and potential future innovations in regenerative medicine.

This study found that microneedles containing magnetic intracellular vesicles and tremella polysaccharide improved the hair microenvironment and accelerated hair regeneration in mice with androgenic alopecia.

This study found that a biocomposite microneedle system, which includes selenium nanozyme and hypoxic extracellular vesicles, enhanced hair density and follicle diameter in androgenetic alopecia mice by fighting inflammation, promoting blood vessel growth, reducing reactive oxygen species, and counteracting androgen effects.

This study developed a gas-propelled microneedle patch with puerarin/quercetin nanoparticles, which demonstrated improved hair-regenerating effects in an androgenetic alopecia mouse model by increasing drug delivery, alleviating oxidative stress, promoting angiogenesis, and rejuvenating senescent cells.

This study describes the development of microneedle array patches for finasteride that released the drug over 7 to 14 days in vitro, suggesting a potential alternative to oral treatments for long-term management of benign prostatic hyperplasia and androgenic alopecia.

In this study, researchers developed a polyphenol–amino acid nanozyme capable of controlled hydrogen peroxide delivery, which effectively activated hair follicles via oxidative stress in a mouse model, suggesting a potential non-pharmacological treatment for alopecia.

This article provides guidelines and indices for a three-point cantilever bending test to measure mechanical properties of hair treated with both conventional and naturally-derived styling polymers, reporting no new experimental results.

This study found that a novel hybrid bilayer scaffold system enhanced wound healing in an in-vivo model by promoting cell viability, migration, and preventing infection, showing potential as an advanced dressing for cutaneous wounds.