Dexmedetomidine-Loaded Hydrogel Microneedles Alleviate Acute Inflammatory Visceral Pain in Mice

    November 2025 in “ Gels ”
    Peng Ke, Xin Tan, Yi Zhou … Xiaodan Wu
    Studysummary This study found that Dex-loaded hyaluronic acid hydrogel microneedles significantly reduced pain in an acute inflammatory visceral pain model without sedation, suggesting a promising and patient-friendly alternative to intravenous delivery.
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    Research cited in this study 4

    1. Microneedle Delivery Platform Integrated With Codelivery Nanoliposomes for Effective and Safe Androgenetic Alopecia Treatment ACS Applied Materials & Interfaces · 2024
    2. Long-Acting Microneedle Formulations Advanced Drug Delivery Reviews · 2023
    3. Therapeutic Applications and Pharmacoeconomics of Microneedle Technology Expert Review of Pharmacoeconomics & Outcomes Research · 2018
    4. Transcutaneous Implantation of Valproic Acid-Encapsulated Dissolving Microneedles Induces Hair Regrowth Biomaterials · 2018