Nano-Spanlastics-Loaded Dissolving Microneedle Patches for Ketotifen Fumarate: Advanced Strategies for Allergic Conjunctivitis Treatment and Molecular Insights

    February 2025 in “ Drug Delivery and Translational Research ”
    Sammar Fathy Elhabal, Mohamed A. El-Nabarawi, Mohamed Fathi Mohamed Elrefai, Mahmoud H. Teaima, Mai S. Shoela, Gehad Khamis, Ahmed Faheem, Nada ahmed kholeif, Mahmoud Tarek Sanad
    TLDR The microneedle patches effectively treat allergic conjunctivitis with controlled, sustained release of medication.
    This study presents a novel approach for treating allergic conjunctivitis (AC) using ketotifen fumarate (KF) loaded into spanlastics nano-vesicular carriers and incorporated into PVA/PVP dissolving microneedle patches. The optimized formulation demonstrated a small particle size, high zeta-potential, and entrapment efficiency, leading to a controlled 93% cumulative release over 72 hours with a zero-order kinetic profile. Pharmacodynamic evaluations showed significant reductions in inflammatory markers IgE, TNF-α, and IL-6, while increasing TGF-β and IL-10 levels, indicating effective anti-inflammatory effects. Gene expression analysis further supported the therapeutic potential, suggesting that this targeted, sustained release system could offer prolonged ocular therapy for AC.
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