Composite Double-Layer Microneedle Loaded With Traditional Chinese Medicine for the Treatment of Androgenic Alopecia

February 2023 in “ Medicine in novel technology and devices ”

Ruoxi Wang, Jiangge Wang, Haiqiang Gao, Xiangyi Liao, Chunyang Ma, Xufeng Niu

composite double-layer microneedles Polygonum multiflorum extract androgenic alopecia polydimethylsiloxane mold hair regrowth hair follicles histological analysis MNs AGA hair regeneration

Studysummary This study found that microneedle delivery of Polygonum multiflorum extract led to earlier pigmentation and hair regrowth in mice with androgenetic alopecia. Our plain-language summary of this paper — not a Tressless recommendation.

Researchers developed composite double-layer microneedles (MNs) loaded with Polygonum multiflorum extract to treat androgenic alopecia (AGA). These MNs, made using a polydimethylsiloxane mold, showed good mechanical properties and gradual drug release. In animal experiments, the MNs promoted earlier pigmentation and hair regrowth, with histological analysis revealing increased number and diameter of hair follicles. The study suggests that these MNs are a promising strategy for AGA treatment by effectively enhancing hair regeneration.

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