Nitrogen-Boosted H2O2 Production of Arginine-Polyphenol Nanozyme Drives Oxidative Eustress for Hair Regeneration

    November 2025 in “ Advanced Science ”
    Yifei Wang, Yaojia Yang, Aoxue Wang, Chen Shen, Shenliang Tan, Changsheng Liu, Yuzheng Zhao, Xue Qu
    TLDR A new nanozyme using EGCG and L-arginine boosts hair growth by safely increasing beneficial oxidative stress.
    The study introduces a novel polyphenol–amino acid nanozyme (PEAs) that enhances H2O2 production to drive oxidative eustress, promoting hair regeneration. By combining epigallocatechin gallate (EGCG) and L-arginine (L-Arg), the nanozyme facilitates controlled H2O2 generation, which is crucial for activating hair follicles. In a mouse model of telogen effluvium, this controlled delivery of H2O2 upregulates Wnt/β-catenin and downregulates Ca2+/calcineurin/NFAT pathways, leading to significant follicle activation. This approach offers a non-pharmacological, safe, and effective strategy for treating alopecia by harnessing beneficial oxidative stress for tissue renewal.
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