Eflornithine Hydrochloride-Loaded Electrospun Nanofibers as a Potential Face Mask for Hirsutism Application

September 2023 in “ Pharmaceutics ”

Shuruq S. Almuwallad, Dunia A. Alzahrani, Walaa S. Aburayan, Ahmed J. Alfahad, Khulud A. Alsulami, Alhassan H. Aodah, Samar A. Alsudir, Sulaiman S. Alhudaithi, Essam A. Tawfik

eflornithine hydrochloride electrospun nanofibers hirsutism polyvinyl pyrrolidone hyaluronic acid in vitro tests in vivo tests hair growth reduction EFH PVP HA

TLDR The new face mask with Eflornithine can potentially reduce facial hair growth and moisturize skin.

The study investigates the use of eflornithine hydrochloride (EFH)-loaded electrospun nanofibers as a potential face mask for treating hirsutism. The nanofibers, made from polyvinyl pyrrolidone and hyaluronic acid, showed high encapsulation efficiency (88 ± 7%) and rapid drug release (80% within 5 minutes). In vitro tests confirmed high cell viability (>90%) and low toxicity. In vivo tests on mice indicated a reduction in hair growth, with 50% of drug-treated mice showing noticeable hair growth by day 21, compared to 75% in the control group. These findings suggest that EFH-loaded nanofibers could be an effective and safe topical treatment for hirsutism.

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19 citations , April 2018 in “JAMA”

Treat hirsutism in premenopausal women with oral contraceptives and consider additional treatments if needed.

research Endocrine Evaluation of Hirsutism

29 citations , March 2017 in “International Journal of Women's Dermatology”

Women with excessive male-pattern hair growth should get a full hormone check-up to find and treat any underlying issues, considering both medical and emotional aspects.

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24 citations , September 2014 in “Drug Delivery”

Using microneedles before applying eflornithine cream can make it more effective at stopping hair growth.

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26 citations , July 2012 in “Journal of family planning and reproductive health care”

The document says that hirsutism in women usually needs hair removal and hormone treatment to manage symptoms and improve well-being.

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54 citations , June 2006 in “Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism”

Medicines that lower androgen levels and hair removal treatments help manage excessive hair and acne in women with PCOS.

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195 citations , May 2003 in “Obstetrics and gynecology (New York. 1953. Online)/Obstetrics and gynecology”

Most women with excess hair growth have an underlying hormonal issue, often treated with medication and hair removal methods.

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115 citations , January 2001 in “American journal of clinical dermatology”

Eflornithine cream effectively reduces women's unwanted facial hair but hair returns if treatment stops.