Eflornithine Hydrochloride-Loaded Electrospun Nanofibers as a Potential Face Mask for Hirsutism Application

September 2023 in “ Pharmaceutics ”

Shuruq S. Almuwallad, Dunia A. Alzahrani, Walaa S. Aburayan, Ahmed J. Alfahad, Khulud A. Alsulami, Alhassan H. Aodah, Samar A. Alsudir, Sulaiman S. Alhudaithi, Essam A. Tawfik

eflornithine hydrochloride electrospun nanofibers hirsutism polyvinyl pyrrolidone hyaluronic acid in vitro tests in vivo tests hair growth reduction EFH PVP HA

TLDR The new face mask with Eflornithine can potentially reduce facial hair growth and moisturize skin.

The study investigates the use of eflornithine hydrochloride (EFH)-loaded electrospun nanofibers as a potential face mask for treating hirsutism. The nanofibers, made from polyvinyl pyrrolidone and hyaluronic acid, showed high encapsulation efficiency (88 ± 7%) and rapid drug release (80% within 5 minutes). In vitro tests confirmed high cell viability (>90%) and low toxicity. In vivo tests on mice indicated a reduction in hair growth, with 50% of drug-treated mice showing noticeable hair growth by day 21, compared to 75% in the control group. These findings suggest that EFH-loaded nanofibers could be an effective and safe topical treatment for hirsutism.

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Research cited in this study

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Eflornithine Hydrochloride-Loaded Electrospun Nanofibers as a Potential Face Mask for Hirsutism Application

Research cited in this study

research Evaluation and Treatment of Hirsutism in Premenopausal Women

research Endocrine Evaluation of Hirsutism

research A Method to Improve the Efficacy of Topical Eflornithine Hydrochloride Cream

research The Investigation and Management of Hirsutism

research A randomized bilateral vehicle-controlled study of eflornithine cream combined with laser treatment versus laser treatment alone for facial hirsutism in women

research Randomized, double‐blind clinical evaluation of the efficacy and safety of topical eflornithine HCl 13.9% cream in the treatment of women with facial hair

research Treatment of Hirsutism and Acne in Hyperandrogenism

research The Evaluation and Management of Hirsutism

research Vaniqa--eflornithine 13.9% cream.

research Topical Eflornithine: Efficacy in Reducing Unwanted Facial Hair Growth in Women

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