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GlossaryProtein-Protein Interaction Network

complex web of interactions between different proteins within cells

A Protein-Protein Interaction Network (PPI Network) is a complex web of interactions between different proteins within a cell. These interactions are crucial for various biological processes, such as cell signaling, metabolism, and structural organization. Understanding PPI Networks helps scientists identify how proteins work together to maintain cellular functions and can provide insights into diseases like alopecia, where these interactions may be disrupted.

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Construction of Regulatory Network for Alopecia Areata Progression and Identification of Immune Monitoring Genes Based on Multiple Machine-Learning Algorithms

research Construction of Regulatory Network for Alopecia Areata Progression and Identification of Immune Monitoring Genes Based on Multiple Machine-Learning Algorithms

3 citations, May 2023 in “Precision clinical medicine”

Researchers found four genes that could help diagnose severe alopecia areata early.

research Elucidating the Anti-Aging Mechanism of Si Jun Zi Tang by Integrating Network Pharmacology and Experimental Validation In Vivo

6 citations, May 2022 in “Aging”

Si Jun Zi Tang may slow aging by affecting specific cell signaling pathways.

research Bioinformatics Analysis of Genes Associated with Patchy-Type Alopecia Areata: CD2 May Be a New Therapeutic Target

4 citations, September 2019 in “Biomedical Papers/Biomedical Papers of the Faculty of Medicine of Palacký University, Olomouc Czech Republic”

CD2 might be a new treatment target for patchy alopecia areata.

research Computational Drug Discovery in Chemotherapy-Induced Alopecia via Text Mining and Biomedical Databases

3 citations, April 2019 in “Clinical Therapeutics”

Computational tools identified 29 drugs that could potentially target 19 genes involved in chemotherapy-induced hair loss, which could lead to more effective treatments.

research Identification of Key Genes in Type 2 Diabetes-Induced Erectile Dysfunction Rats with Stem Cell Therapy Through High-Throughput Sequencing and Bioinformatic Analysis

2 citations, March 2021 in “Andrologia”

Stem cell therapy affects 15 key genes in rats with diabetes-related erectile dysfunction.

research Application of Multi-Omics Techniques to Androgenetic Alopecia: Current Status and Perspectives

June 2024 in “Computational and Structural Biotechnology Journal”

Multi-omics techniques help understand the molecular causes of androgenetic alopecia.

research Disturbance of Immune Microenvironment in Androgenetic Alopecia Through Spatial Transcriptomics

August 2024 in “International Journal of Molecular Sciences”

Androgenetic alopecia involves immune cell disruptions, especially increased CD4+ T cells around hair follicles.

research Pathway Enrichment and Network Analysis of Differentially Expressed Genes in Pashmina Goat

1 citations, June 2022 in “Gene reports”

The analysis found genes linked to skin and hair development are more active in Pashmina goats, which may explain their long-fiber production.

research RNA Sequence Analysis of Dermal Papilla Cells’ Regeneration in 3D Culture

6 citations, October 2020 in “Journal of Cellular and Molecular Medicine”

3D culture helps maintain hair growth cells better than 2D culture and identifies key genes for potential hair loss treatments.

research Integration Analysis of Transcriptome and Proteome Reveals the Mechanisms of Goat Wool Bending

6 citations, April 2022 in “Frontiers in cell and developmental biology”

The research identified key proteins and genes that may influence wool bending in goats.

research Differential Proteomics of Lesional vs. Non-Lesional Biopsies Revealed Non-Immune Mechanisms of Alopecia Areata

19 citations, January 2018 in “Scientific Reports”

Non-immune factors play a significant role in alopecia areata.

Proteomic Analysis of Fetal Skin by iTRAQ Reveals Molecular Signals Underlying Inner Mongolia Cashmere Goat Hair Follicle Initiation

research Proteomic Analysis of Fetal Skin by iTRAQ Reveals Molecular Signals Underlying Inner Mongolia Cashmere Goat Hair Follicle Initiation

1 citations, February 2023 in “All Life”

The research identified proteins that change as goat hair follicles begin to form, helping to understand how cashmere grows.

research Identification of Potential miRNA–mRNA Regulatory Network Associated with Growth and Development of Hair Follicles in Forest Musk Deer

December 2023 in “Animals”

The research found genes and miRNAs that may control hair growth in Forest Musk Deer.

research New Target for Minoxidil in the Treatment of Androgenetic Alopecia

August 2023 in “Drug Design Development and Therapy”

Minoxidil may work for hair loss by reducing androgen sensitivity and altering hormone-related enzymes.

research Enriching Proteolysis Targeting Chimeras with a Second Modality: When Two Are Better Than One

10 citations, July 2022 in “Journal of Medicinal Chemistry”

Adding a second method to PROTACs could improve cancer treatment.

Proteomic Identification and Quantification of Secretory Proteins in Human Dermal Fibroblast-Conditioned Medium for Wound Repair and Hair Regeneration

research Proteomic Identification and Quantification of Secretory Proteins in Human Dermal Fibroblast-Conditioned Medium for Wound Repair and Hair Regeneration

May 2023 in “Clinical, Cosmetic and Investigational Dermatology”

The research found proteins in human skin cells that help with wound healing and hair growth, which could lead to new treatments.

research Network-Based Drug Repositioning: Approaches, Resources, and Research Directions

39 citations, December 2018 in “Methods in molecular biology”

The document concludes that computational methods using networks and various data can improve the process of finding new uses for existing drugs.

Bioinformatic Analysis of Gene Expression Data Reveals Src Family Protein Tyrosine Kinases as Key Players in Androgenetic Alopecia

research Bioinformatic Analysis of Gene Expression Data Reveals Src Family Protein Tyrosine Kinases as Key Players in Androgenetic Alopecia

June 2023 in “Frontiers in Medicine”

Protein tyrosine kinases are key in male pattern baldness, affecting skin structure, hair growth, and immune responses.

research Comparative Proteomic Analysis in Scar-Free Skin Regeneration in Acomys Cahirinus and Scarring Mus Musculus

13 citations, January 2020 in “Scientific Reports”

The African spiny mouse heals skin without scarring due to different protein activity compared to the common house mouse, which heals with scarring.

Molecular Functional Analyses Revealed Essential Roles of HSP90 and Lamin A/C in Growth, Migration, and Self-Aggregation of Dermal Papilla Cells

research Molecular Functional Analyses Revealed Essential Roles of HSP90 and Lamin A/C in Growth, Migration, and Self-Aggregation of Dermal Papilla Cells

10 citations, May 2018 in “Cell death discovery”

HSP90 and lamin A/C are crucial for hair growth and could be targets for treating hair loss.

research Identification of the Key Proteins Associated With Different Hair Types in Sheep and Goats

2 citations, September 2022 in “Frontiers in genetics”

Different proteins are linked to the varying thickness of sheep and goat hair types.

Label-Free Proteomics to Identify Keratins and Keratin-Associated Proteins and Their Effects on the Fleece Traits of Inner Mongolia Cashmere Goats

research Label-Free Proteomics to Identify Keratins and Keratin-Associated Proteins and Their Effects on the Fleece Traits of Inner Mongolia Cashmere Goats

January 2023 in “Czech Journal of Animal Science”

Proteins influence the quality and traits of cashmere goat fleece, affecting hair strength and diameter.

research Integrated miRNA and mRNA Analysis Provides New Insight into Mechanism of Dermal Papilla in Androgenetic Alopecia

June 2024 in “Research Square (Research Square)”

Increased cell death and reduced cell growth in hair follicles contribute to baldness.

research Cutaneous Transcriptome Analysis in NIH Hairless Mice

7 citations, August 2017 in “PloS one”

Key genes linked to hair growth and cancer were identified in hairless mice.

Cloning, Computational Analysis and Expression Profiling of Steroid 5 Alpha-Reductase 1 (SRD5A1) Gene During Reproductive Phases and Ovatide Stimulation in Endangered Catfish, Clarias Magur

research Cloning, Computational Analysis and Expression Profiling of Steroid 5 Alpha-Reductase 1 (SRD5A1) Gene During Reproductive Phases and Ovatide Stimulation in Endangered Catfish, Clarias Magur

November 2023 in “Scientific reports”

The research identified and described a gene important for hormone conversion in endangered catfish, which varies in activity during different reproductive stages and after hormone treatment.

Editorial: Machine Learning Techniques on Gene Function Prediction Volume II

research Integration Analysis of Hair Follicle Transcriptome and Proteome Reveals the Mechanisms Regulating Wool Fiber Diameter in Angora Rabbits

March 2024 in “International journal of molecular sciences”

The research identified key proteins that affect wool fiber thickness in Angora rabbits.

research Genome-Wide Detection of RNA Editing Events During the Hair Follicles Cycle of Tianzhu White Yak

October 2022 in “BMC genomics”

RNA editing significantly affects hair growth and follicle cycling in the Tianzhu white yak.