Pathway Enrichment and Network Analysis of Differentially Expressed Genes in Pashmina Goat

June 2022 in “ Gene reports ”

Rashid Saif, Tania Mahmood, Aniqa Ejaz, Saeeda Zia

differentially expressed genes DEGs up-regulated genes down-regulated genes skin development barrier development peptide cross-linking epidermis development intermediate filament cytoskeleton protein binding GTPase regulator activity microtubule cytoskeleton adhesion molecules genes skin epidermis protein cytoskeleton

TLDR The analysis found genes linked to skin and hair development are more active in Pashmina goats, which may explain their long-fiber production.

The study analyzed differentially expressed genes (DEGs) in Pashmina goats, known for their warm and fine cashmere fiber. The researchers used 152 up-regulated and 919 down-regulated genes from a previous study for functional profiling, annotations, and network analysis. The study found that the up-regulated genes were mostly involved in skin and barrier development, peptide cross-linking, regulation of cellular component movement, epidermis development, and intermediate filament cytoskeleton-based processes and organization. The down-regulated genes, essential for normal functioning, were involved in protein binding, GTPase regulator activity, structural and functional support to microtubule cytoskeleton, and adhesion molecules. This research provides insights into the genetic factors contributing to the Pashmina goat's unique traits, particularly its high-quality cashmere production.

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