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Research

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research Forkhead/winged-helix transcription factor whn regulates hair keratin gene expression: Molecular analysis of theNude skin phenotype

75 citations , April 2000 in “Developmental Dynamics”

This study suggests that the structural integrity and physical proximity of Whn's DNA binding and activation domains are crucial for hair keratin gene activation and may explain the nude phenotype.

research Identification of androgen-regulated genes in SV40-transformed human hair dermal papilla cells

12 citations , May 2003 in “Journal of dermatological science”

This study found that the heat shock cognate protein Hsc70 was differentially expressed by dihydrotestosterone treatment in SV40-transformed dermal papilla cells, suggesting its involvement in androgen action on these cells.

research Association of Autoimmune Regulator Gene Rs2075876 Variant, but Not Gene Expression with Alopecia Areata in Males: A Case–control Study

8 citations , October 2019 in “Immunological investigations”

This study suggests that the rs2075876 variant in the AIRE gene may significantly increase susceptibility to alopecia areata in the examined male population.

research Identification of immune microenvironment changes, immune-related pathways and genes in male androgenetic alopecia

September 2023 in “Medicine”

This study found increased infiltration of specific immune cells, such as γδ T cells and CD8+ T cells, in the bald scalp of male androgenetic alopecia patients, and identified four key immune-related genes potentially involved in hair loss development through interferon-γ signaling pathways.

research Bioinformatics analysis and verification of m6A related genes based on the construction of keloid diagnostic model

January 2023 in “Research Square (Research Square)”

This study identified m6A-related genes, particularly IGF2BP3, as significantly up-regulated in keloid patients, potentially implicating them in the condition's molecular mechanisms and suggesting targets for therapy.

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Community Join

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community How many of you guys have taken accutane?

in Chat 8 upvotes 1 year ago

Accutane may accelerate hair loss in genetically predisposed individuals by affecting enzymes related to DHT metabolism. Some users report hair loss after taking Accutane, while others use treatments like finasteride and minoxidil to manage hair loss.

community Why is Minoxidil not enough for hair loss? (No fin)

59 upvotes 1 year ago

Minoxidil alone is often insufficient for treating hair loss because it doesn't address the DHT-related cause. Combining it with finasteride, a DHT blocker, is generally more effective.

community What do you guys think about Stem cell treatments

4 upvotes 5 years ago

Stem cell and exosome injections for hair loss are discussed, with skepticism about their effectiveness and concerns about using non-genetically related stem cells. Dr. Deyarmin's treatments are mentioned, with some users questioning their legitimacy and others expressing curiosity.

community Is PP405 formula available in grey market?

16 upvotes 1 year ago

The conversation is about the availability of the PP405 formula for hair loss treatment, with mentions of finasteride and its side effects. Users discuss the potential of obtaining the formula through unofficial channels and the challenges related to its genetic sequence and delivery method.

community 22M on Min/Fin for 3 Months: Concerns About Side Effects and Accutane Interaction

in General 108 upvotes 10 months ago

A 22-year-old is using minoxidil and finasteride for hair loss and is concerned about side effects and interactions with Accutane. Continuing these treatments may help prevent Accutane-related hair loss, but stopping them could reverse progress.

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Learn

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learn Rapamycin

mTOR regulator and immunosuppressant used more recently for anti-aging and hair regrowth

learn Follistatin

glycoprotein that inhibits TGF-β and promotes hair growth by antagonizing activin

learn Procyanidin

bioflavonoid found in plants with antioxidant and hair stimulating properties

learn Fluridil

a topical anti-androgen with less systemic involvement

learn sh-Polypeptide-7

learn RU58841

RU58841: Is it easy to get or is it an impossible mission? RU58841 is not approved as a medicine anywhere and is sold only as an unregulated 'research chemical', so identity and purity are unverified; the published evidence stops at animal and tissue studies, with no human trial.

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Clinics

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All 68 clinic results →

Experts

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Hair System Specialist
Jane Genesi
Marlton, PA, United States

Jane Genesi