August 2024 in “Scholars Journal of Applied Medical Sciences” This study found that combining platelet-rich plasma therapy with minoxidil significantly improved hair growth and hair follicle cell proliferation in men with androgenetic alopecia compared to either treatment alone.
March 2024 in “Intisari Sains Medis” This narrative review reported that intradermal injection of autologous platelet-rich plasma showed objective improvement and increased patient satisfaction in treating periorbital wrinkles, though the authors noted the need for further rigorous studies to confirm these findings.
This study concluded that using Plasma gel and PRP as autologous collagen biostimulators improved acne scars and skin density, demonstrating efficiency and safety for facial rejuvenation in clinical evaluations including patient satisfaction.
This review discusses the potential of extracellular vesicles from various sources for skin rejuvenation and cosmetic use, noting promising results, especially with mesenchymal stem cell-derived vesicles, but reports no new clinical results.
September 2021 in “Meditsinskiy sovet = Medical Council” This study found that injecting blood plasma enriched with platelet growth factors significantly improved the healing and auditory function in patients with acute post-traumatic tympanic membrane perforation compared to natural regeneration.
September 2021 in “Farmacja Polska” In this summary of needle mesotherapy's role in treating alopecia, the researchers highlight its use in delivering beneficial substances directly to the skin or hair follicles, showing hair loss reduction after one treatment and hair regrowth after several sessions, although contraindications exist for certain populations.
December 2019 in “Medicina estética/Medicina estética” This review discusses the use of platelet-rich plasma as an adjunctive treatment for patients undergoing hair transplant and reports no clinical results; the authors suggest it could be beneficial but emphasize the need for scientific evidence.
December 2019 in “Medicina estética/Medicina estética” This review examines the current scientific evidence on using platelet-rich plasma as an adjunctive treatment for patients undergoing hair transplant but reports no new clinical findings.
January 2019 in “Springer eBooks” Platelet-rich plasma therapy may have benefits and is generally safe, but more research is needed to confirm its effectiveness and safety.
January 2021 in “Journal of cosmetology & trichology” This review discusses platelet-rich plasma treatment for androgenetic alopecia, addressing its effectiveness, challenges, and future directions, but reports no new clinical results.
October 2024 in “Stem Cell Research & Therapy” This study found that CGF may be effective in reducing inflammation and improving skin conditions in psoriasis, particularly in patients resistant to other treatments.
June 2026 in “Journal of Cosmetic Dermatology” CGF-PF may improve hair loss treatment by targeting hair follicle stem cells more effectively.
April 2026 in “Journal of Dermatological Treatment” This study concluded that in female pattern hair loss patients, CGF and i-PRF treatments were more effective than PRP in increasing target area hair count, with i-PRF having the lowest adverse event rate.
23 citations
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September 2020 in “Journal of Cosmetic Dermatology” This review discusses the potential applications of injectable platelet‐rich fibrin in various conditions and reports no new clinical results; the authors highlight its favorable use in comparison to existing treatments.
103 citations
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June 2018 in “International Journal of Molecular Sciences” This review discusses the applications and research on fibroblast growth factors, including their use in wound healing, diabetes, and cancer, but it reports no new clinical results.
March 2026 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, researchers developed a new method called Enriched-GF, which enhances growth factor recovery from platelet concentrates through a combination of glass bead activation, freeze-thaw cycling, and calcium stimulation, outperforming conventional methods by providing higher and more consistent yields for regenerative medicine applications.
31 citations
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February 2014 in “Journal of dermatological science” This study found that placental growth factor (PlGF) enhanced hair shaft elongation and accelerated hair follicle growth, suggesting its potential as a therapeutic target for alopecia.
September 2020 in “Revista Digital de Postgrado” This review discusses the characteristics and dermatological applications of platelet-rich plasma and fibrin meshes and reports no new clinical results.
6 citations
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October 2024 in “Frontiers in Bioengineering and Biotechnology” This study reported that the use of composite RGDmix hydrogel improved the survival and proliferation of human amniotic mesenchymal stem cells and increased growth factor expression, enhancing wound healing through the RGDSP/integrin αv/PI3K/AKT signaling pathway.
December 2022 in “Plastic and Reconstructive Surgery” In this study, PRPF treatment was more effective than PRP alone in improving hair count and hair quality in androgenetic alopecia patients, with PRPF showing significant improvements in various hair growth parameters and having no statistical differences observed in the placebo group.
This review summarizes the roles of PDGF and its receptors in cell development and wound healing, reporting no new research findings; the authors emphasize PDGF's diverse biological functions.
January 2016 in “Más dermatología” This review discusses the expanding use of platelet-rich plasma (PRP) in chronic ulcer treatment and aesthetics but reports no new clinical findings; PRP's composition, including growth factors, relates to tissue repair and potential hair growth.
7 citations
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December 2024 in “Journal of Functional Biomaterials” This review discusses the role of advanced platelet-rich fibrin (A-PRF) in oral and maxillofacial surgery, highlighting its potential benefits for healing, pain relief, and graft integration, with a need for more clinical trials to confirm long-term effects.
April 2022 in “The Egyptian Journal of Hospital Medicine” This review examines the use of platelet rich fibrin for treating post-acne scars and reports no new clinical results; it highlights that fibrin's matrix enables a prolonged release of growth factors.
2 citations
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April 2012 in “Science-business Exchange” Blocking a protein called prostaglandin D2 might help treat hair loss.
24 citations
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July 1994 in “Molecular Endocrinology” Researchers found an RNA transcript that might help control a growth factor linked to tumor development.
219 citations
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July 1995 in “PubMed” This study found that recombinant keratinocyte growth factor (rKGF) stimulated hair growth and provided a protective effect against alopecia in murine models, suggesting its role in hair follicle development and regeneration.
2 citations
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October 2021 in “Experimental Cell Research” This study found that injectable platelet-rich fibrin (i-PRF) enhances hair follicle regeneration in vitro by promoting human dermal papilla cell proliferation, migration, and trichogenic inductivity, with varying effects depending on concentration.
4 citations
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October 2024 in “BMC Oral Health” This review suggests that PRF may be a promising alternative treatment for oral mucosal lesions, but further research is needed to confirm its long-term effectiveness and standardize preparation protocols.
June 2025 in “Dermatologic Surgery” This study found that growth factor concentrate provides quicker improvements for patterned hair loss, but platelet-rich plasma offers more sustained benefits after treatment.