Clinical Efficacy of PRP Therapy, Minoxidil, and Their Combination in the Treatment of Men with Androgenetic Alopecia

August 2024 in “ Scholars Journal of Applied Medical Sciences ”

Maruna Yesmeen, Farhana Haque

PRP therapy minoxidil androgenetic alopecia β-catenin CD34 Ki67+ hair follicle cell proliferation PRP Rogaine AGA

TLDR Combining PRP therapy with minoxidil is the most effective treatment for hair loss in men.

This study compared the efficacy of PRP therapy, minoxidil, and their combination in treating 69 men with androgenetic alopecia (AGA). Results showed that PRP therapy was more effective than minoxidil alone (p = 0.005), and the combination therapy significantly outperformed both minoxidil (p < 0.0001) and PRP monotherapy (p = 0.007). PRP application increased the expression of β-catenin, CD34, and the Ki67+ index, indicating enhanced hair follicle cell proliferation. The study concludes that PRP is a viable treatment for AGA, and combining it with minoxidil can further improve treatment outcomes.

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2 / 2 results

research Twenty Nail Dystrophy with Alopecia Areata in an Atopic Child

April 2019 in “International journal of research in dermatology”

A child with rough nails also had hair loss and allergies.

research Effectivity of Minoxidil as a Treatment for Alopecia Areata

January 2014 in “DOAJ (DOAJ: Directory of Open Access Journals)”

The document discussed the effectiveness of minoxidil as a treatment for alopecia areata, a condition characterized by patchy hair loss. It highlighted that minoxidil had been known for over 30 years to stimulate hair growth by working on hair follicles, opening potassium channels, and increasing blood flow. Histological studies showed that minoxidil therapy could increase the proportion of hair follicles in the anagen phase and decrease those in the telogen phase. Additionally, minoxidil at micromolar concentrations stimulated cell proliferation, while at millimolar concentrations, it inhibited growth. The document also mentioned that minoxidil's vascular effects and stimulation of VEGF could promote hair follicle growth.