RGDSP-Functionalized Peptide Hydrogel Stimulates Growth Factor Secretion Via Integrin αv/PI3K/AKT Axis for Improved Wound Healing by Human Amniotic Mesenchymal Stem Cells

October 2024 in “ Frontiers in Bioengineering and Biotechnology ”

Wei Wei, Lei Huang, Luoying Chen, Huanhuan He, Yanfei Liu, Yuan Ping Feng, Feng-Qin Lin, Hui Chen, Qing‐Yu He, Junhong Zhao, Haihong Li

RGDSP-functionalized peptide hydrogel human amniotic mesenchymal stem cells integrin αv PI3K/AKT pathway epidermal maturation hair follicle formation growth factors EGF bFGF VEGF TGF-β angiogenesis wound re-epithelialization epidermal growth factor basic fibroblast growth factor vascular endothelial growth factor transforming growth factor beta

From the encyclopedia

Epidermal Growth Factor →

Vascular Endothelial Growth Factor →

Studysummary This study reported that the use of composite RGDmix hydrogel improved the survival and proliferation of human amniotic mesenchymal stem cells and increased growth factor expression, enhancing wound healing through the RGDSP/integrin αv/PI3K/AKT signaling pathway.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

This study examines the use of RGDSP-functionalized peptide hydrogels to enhance wound healing by human amniotic mesenchymal stem cells (hAMSCs). The hydrogels improve the secretion of growth factors like EGF, bFGF, VEGF, and TGF-β via the integrin αv/PI3K/AKT pathway, promoting wound re-epithelialization, angiogenesis, and epidermal maturation, including hair follicle formation. The study, conducted on a murine model, shows that the RGDmix hydrogel significantly accelerates wound healing, achieving complete wound closure by day 21. This research underscores the potential of these hydrogels in regenerative medicine by enhancing the paracrine function of hAMSCs and suggests further optimization for clinical applications.

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