RGDSP-Functionalized Peptide Hydrogel Stimulates Growth Factor Secretion Via Integrin αv/PI3K/AKT Axis for Improved Wound Healing by Human Amniotic Mesenchymal Stem Cells

October 2024 in “ Frontiers in Bioengineering and Biotechnology ”

Wei Wei, Lei Huang, Luoying Chen, Huanhuan He, Yanfei Liu, Yuan Ping Feng, Feng-Qin Lin, Hui Chen, Qing‐Yu He, Junhong Zhao, Haihong Li

TLDR A special hydrogel helps stem cells heal wounds better by boosting growth factors.

This study explored the use of RGDmix hydrogel to enhance wound healing by supporting the survival and proliferation of human amniotic mesenchymal stem cells (hAMSCs). The hydrogel increased the expression of growth factors, promoting wound re-epithelialization, angiogenesis, and epidermal maturation. The research highlighted the role of the integrin αv and PI3K/AKT signaling pathways in growth factor secretion, demonstrating that the RGDmix hydrogel improved therapeutic outcomes in wound healing through the RGDSP/integrin αv/PI3K/AKT axis.

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