Role of Platelet-Rich Fibrin in the Treatment of Post-Acne Scars: Review Article

    April 2022 in “ The Egyptian Journal of Hospital Medicine ”
    Nagwa Diab, Aya Mohamed Abdallah, AlShimaa Mohamed Ibrahim
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    TLDR Platelet Rich Fibrin improves healing and reduces acne scars by slowly releasing growth factors.
    The article "Role of Platelet Rich Fibrin (PRF) in Treatment of Post Acne Scars" reviews the potential use of PRF in treating acne scars. Acne scars, which negatively impact personal and professional relationships, are primarily caused by abnormal collagen creation or breakdown during healing. The majority of these scars are atrophic, resulting from collagen degradation at the dermal level. PRF was introduced into acne scar treatment after platelet-derived growth factor (PDGF) was found to stimulate wound healing, angiogenesis, and tissue remodeling. The study concludes that cell migration and proliferation are more efficient when fibrin is rich in platelets. Compared to platelet-rich plasma, the fibrin matrix allows for a slow and steady release of growth factors over time.
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