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    Glossary Peroxisome Proliferator-Activated Receptors

    regulate gene expression related to metabolism and inflammation

    Peroxisome Proliferator-Activated Receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes. They play crucial roles in the metabolism of fats and sugars, inflammation, and cell differentiation, making them significant in conditions like diabetes, obesity, and cardiovascular diseases.

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    Research 30 of 890

    1. Preservation of sebaceous glands and peroxisome proliferator-activated receptor gamma expression in central centrifugal cicatricial alopecia Journal of The American Academy of Dermatology · 2018 · 1 citations
    2. Peroxisome Proliferator Activated Receptors Gamma Serum levels and Gene Polymorphism in Frontal Fibrosing Alopecia: A Case Control Study Research Square (Research Square) · 2022
    3. Peroxisome Proliferator Activated Receptor-Gamma Tissue Expression and Gene Polymorphism in Alopecia Areata in an Egyptian Sample Benha Journal of Applied Sciences · 2023
    4. Expression of Peroxisome Proliferator Activated Receptors (PPARs) in Human Hair Follicles and PPARα Involvement in Hair Growth Acta dermato-venereologica · 2000 · 51 citations
    5. Peroxisome Proliferator–Activated Receptor-γ−Mediated Signaling Regulates Mitochondrial Energy Metabolism in Human Hair Follicle Epithelium Journal of Investigative Dermatology · 2018 · 17 citations
    6. Peroxisome proliferator-activated receptor-γ signalling protects hair follicle stem cells from chemotherapy-induced apoptosis and epithelial–mesenchymal transition 2021 · 19 citations
    7. Contributions of peroxisome proliferator-activated receptor β/δ to skin health and disease BioMolecular Concepts · 2012 · 12 citations
    8. Functions of peroxisome proliferator‐activated receptors (PPAR) in skin homeostasis Lipids · 2004 · 46 citations
    9. 223 Canonical and Dominant Negative Peroxisome Proliferator-Activated Receptor γ Isoforms are Differentially Expressed in Human Skin and Skin Appendages 2022
    10. Palmitoylethanolamide Stimulation Induces Allopregnanolone Synthesis in C6 Cells and Primary Astrocytes: Involvement of Peroxisome-Proliferator Activated Receptor-α Journal of Neuroendocrinology · 2011 · 52 citations
    11. TGFβ signaling regulates lipogenesis in human sebaceous glands cells BMC Dermatology · 2013 · 44 citations
    12. Expression of steroidogenic enzymes in human sebaceous glands 2014 · 25 citations
    13. Deciphering the Skin Anti-Aging and Hair Growth Promoting Mechanisms of Opophytum forskahlii Seed Oil via Network Pharmacology International Journal of Molecular Sciences · 2025
    14. Inhibition of Cholesterol Biosynthesis Modulates Epithelial-Mesenchymal Transition in Primary Cicatricial Alopecia Through TGFβ and Angiotensin Receptors Journal of Endocrinology and Reproduction · 2023
    15. 1405 Cellular and molecular characterization of sebaceous gland self-renewal and regeneration following complete genetic ablation Journal of Investigative Dermatology · 2023
    16. Differentiation of the sebaceous gland Dermato-Endocrinology · 2009 · 60 citations
    17. The role of nuclear hormone receptors in cutaneous wound repair Cell Biochemistry and Function · 2014 · 68 citations
    18. Mechanisms of Puerariae Lobatae Radix in regulating sebaceous gland secretion: insights from network pharmacology and experimental validation Frontiers in Pharmacology · 2024 · 3 citations
    19. Clinical Pathobiology of Radiotherapy-Induced Alopecia: A Guide toward More Effective Prevention and Hair Follicle Repair 2023 · 3 citations
    20. Sebaceous immunobiology - skin homeostasis, pathophysiology, coordination of innate immunity and inflammatory response and disease associations Frontiers in immunology · 2022 · 21 citations
    21. Adipose and Hair Function: An aPPARent Connection Journal of Investigative Dermatology · 2018 · 7 citations
    22. A new target for squamous cell skin cancer? Experimental Dermatology · 2014 · 6 citations
    23. Hot Stuff: Thermal Imaging Aids in Cellulitis Diagnosis Journal of Investigative Dermatology · 2018 · 4 citations
    24. Treatment of Cultured Sebocytes with an EGFR Inhibitor Does Not Lead to Significant Upregulation of Inflammatory Biomarkers Annals of Dermatology · 2011 · 3 citations
    25. SnapshotDx Quiz: December 2018 Journal of Investigative Dermatology · 2018
    26. 686 Topical melatonin unfolds differential anti-aging effects in human skin by inhibiting mTORC1 activity via TSC2 stimulation Journal of Investigative Dermatology · 2024
    27. Early skin seeding regulatory T cells modulate PPARγ-dependent skin pigmentation bioRxiv (Cold Spring Harbor Laboratory) · 2023
    28. Faculty Opinions recommendation of Hair follicle stem cell-specific PPARgamma deletion causes scarring alopecia. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2009
    29. Lichen Planopilaris Treated With a Peroxisome Proliferator–Activated Receptor γ Agonist Archives of dermatology · 2009 · 105 citations
    30. Epithelial-to-Mesenchymal Stem Cell Transition in a Human Organ: Lessons from Lichen Planopilaris Journal of Investigative Dermatology · 2017 · 71 citations