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GlossaryNuclear Receptors

proteins that regulate gene expression in response to hormones

Nuclear receptors (NRs) are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules. When these receptors bind to their specific ligands, they can directly influence the expression of specific genes, thereby regulating various biological processes such as metabolism, development, and cell differentiation.

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learn Metformin

diabetes drug with anti-inflammatory, immunomodulatory, and insulin-sensitizing properties

Research

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research On the Effects of Testosterone on Brain Behavioral Functions

186 citations , February 2015 in “Frontiers in Neuroscience”

Testosterone affects brain behavior in complex and varied ways.

research Allosteric Interactions Prime Androgen Receptor Dimerization And Activation

1 citations , February 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

Certain interactions help prepare the androgen receptor for pairing and activation, which is important for its role in development and disease.

research Antiandrogens: Clinical Applications

39 citations , November 1990 in “The Journal of Steroid Biochemistry and Molecular Biology”

Antiandrogens help treat hormone-related conditions in both men and women.

research Drug Repositioning Using In Silico Compound Profiling

24 citations , December 2009 in “Future Medicinal Chemistry”

Using computers to analyze drugs can find new uses for them, but actual experiments are needed to confirm these uses.

research Research on Expression of Retinoid-Related Orphan Receptor (ROR) in the Skin of Cashmere Goat

January 2010 in “China Animal Husbandry & Veterinary Medicine”

RORs may influence cashmere growth cycles.

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

nkrata in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Pyrilutamide update: three months

in Update 32 upvotes 3 years ago

A user's 3-month experience with pyrilutamide to reduce hair shedding, and how it may not be strong enough to stop the thinning of their hairline. Other users mentioned the effectiveness of minoxidil and finasteride for treating hair loss.

community 9 months update. 40m, fin/min/ru

in Progress Pictures 211 upvotes 1 year ago

A 40-year-old man shared a 9-month update on his hair loss treatment, which includes 1.25mg finasteride, 8% minoxidil, RU58841, dermarolling, ketoconazole shampoo, and vitamins, with no significant side effects. He has seen improvement in his hair growth and has stopped wearing hats as a result.

community New Research- Creatine Increasing Scalp DHT Without Corresponding Serum DHT Increase

in Research/Science 124 upvotes 1 year ago

Creatine may increase scalp DHT without affecting serum DHT, potentially speeding up male pattern baldness (MPB) for those genetically prone. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community My current nuclear stack. Thoughts?

in Chat 7 upvotes 2 years ago

The user is using RU58841 twice daily, dutasteride 0.5mg every two days, dutasteride mesotherapy every three months, and 20mg oral minoxidil daily. Other users suggest this regimen is excessive and recommend adding microneedling and ketoconazole shampoo.

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