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    GlossaryNuclear Receptors

    proteins that regulate gene expression in response to hormones

    Nuclear receptors (NRs) are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules. When these receptors bind to their specific ligands, they can directly influence the expression of specific genes, thereby regulating various biological processes such as metabolism, development, and cell differentiation.

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      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 1 month ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Pyrilutamide update: three months

      in Update  32 upvotes 1 year ago
      A user's 3-month experience with pyrilutamide to reduce hair shedding, and how it may not be strong enough to stop the thinning of their hairline. Other users mentioned the effectiveness of minoxidil and finasteride for treating hair loss.

      community Trestolone (MENT) as a nuclear treatment

      in Treatment  99 upvotes 2 years ago
      Experimenting with trestolone as a treatment for hair loss in an attempt to avoid DHT-related treatments such as finasteride and dutasteride, and discussing the potential effects of its receptor selectivity on the androgen receptors in the scalp.

      community My current nuclear stack. Thoughts?

      in Chat  6 upvotes 6 months ago
      The user is using RU58841 twice daily, dutasteride 0.5mg every two days, dutasteride mesotherapy every three months, and 20mg oral minoxidil daily. Other users suggest this regimen is excessive and recommend adding microneedling and ketoconazole shampoo.

      community My nuclear protocol (scary but very effective)

      in Treatment  81 upvotes 2 years ago
      A hair loss treatment protocol involving topical and oral medications such as Minoxidil, RU58841, Finasteride, Dutasteride, Melatonin, Zinc, Vitamin B6, NAC, Caffeine, Biotin, Ginseng, and Semen; other treatments including Microneedling, Laser Helmet, Nizoral shampoo, Scalp Massage and supplements like Vitamin C, Vitamin D, Fish Oil, and Biotin; and the potential side effects of using this protocol.

      community Shedding and thinning won’t stop on Nuclear protocol

      in Treatment  21 upvotes 1 year ago
      The user is using a combination of hair loss treatments including dutasteride, minoxidil, RU58841, low-level laser therapy, ketokonozole, supplements, Viviscal, Nutrafol, microneedling, PRP, and scalp Botox injections, but is still experiencing hair shedding and thinning. Despite being on this regimen for two years, the user's hair condition is worsening, and they are seeking advice on what else they can do.

      community Rate my stack! (Using a nuclear protocol)

      in Finasteride/Dutasteride  16 upvotes 3 years ago
      A hair loss regimen involving Dutasteride, Oral Minoxidil, Mesotherapy, Topical Minoxidil/Finasteride, RU58841, Alfatridiol, Microneedling, LLLT, Keto shampoo, Vitamin K/D/Fish oil/Borage Oil/MSM, Oral Castor oil and Niacin. It also mentions products that have been dropped from the regimen due to not being worth the hassle or messing with libido.

      community Anyone excited for CosmeRNA coming this month?

      in Product  171 upvotes 1 year ago
      CosmeRNA, a new hair loss treatment, is expected to release soon and may become part of the "big three" treatments alongside finasteride and minoxidil. It works differently from finasteride by targeting androgen receptors in hair follicles, potentially offering fewer side effects.

      community 40 years old. 5 months progress. New hair coming in daily.

      in Progress Pictures  123 upvotes 1 year ago
      The user "mynameisbogus" shared their hair loss progress using various treatments including Dutasteride, RU, oral minoxidil, topical treatments, microneedling, dermastamping, rosemary oil, and scalp massaging. Other users commented on the extensive regimen and expressed their opinions.

      community blood DHT levels shot up after doubling dutasteride dosage

      in Finasteride/Dutasteride  20 upvotes 4 months ago
      A user increased their dutasteride dosage from 0.5mg to 1mg daily, resulting in a rise in DHT levels from 148 pg/mL to 281 pg/mL, and is considering switching back to finasteride due to continued hair loss. Replies suggest retesting and emphasize the importance of bloodwork before starting treatments.

      community If dutesteride and oral minoxidil doesn’t work that’s it right?

      in Treatment  41 upvotes 5 months ago
      A user is experiencing ongoing hair loss despite using 0.5mg dutasteride and 2.5mg oral minoxidil for several years and is seeking advice. Suggestions include ensuring correct diagnosis, checking for other health issues, considering finasteride, trying topical antiandrogens, and consulting a dermatologist.

      community 9 months update. 40m, fin/min/ru

      in Progress Pictures  210 upvotes 6 months ago
      A 40-year-old man shared a 9-month update on his hair loss treatment, which includes 1.25mg finasteride, 8% minoxidil, RU58841, dermarolling, ketoconazole shampoo, and vitamins, with no significant side effects. He has seen improvement in his hair growth and has stopped wearing hats as a result.

      community Anything stronger than DUT out there?

      in Finasteride/Dutasteride  14 upvotes 6 months ago
      The conversation discusses seeking a stronger treatment than Dutasteride (DUT) for hair loss. Suggestions include combining DUT with RU58841, increasing DUT dosage, and using transgender hormone replacement therapy or testosterone blockers, though some options may have feminizing side effects.

      community Why isn’t oral minoxidil enough for me?

      in Minoxidil  7 upvotes 6 months ago
      A user takes 5mg oral minoxidil, oral dutasteride, topical tretinoin, stemoxydine, topical minoxidil, and uses dermarolling for hair loss but sees less impressive, patchy regrowth compared to others. Another person suggests some online results may be enhanced with hair fibers, not just medication.

      community A Nuanced Look at Microdosing Topical Finasteride

      in Finasteride/Dutasteride  87 upvotes 10 months ago
      The conversation discusses using a low dose of topical finasteride to achieve hair benefits with minimal systemic exposure. Users share experiences and opinions on dosing, systemic buildup, and side effects of both topical and oral finasteride.

      community RU58841 alone vs. with Fin / Dut

      in Finasteride/Dutasteride  11 upvotes 1 year ago
      RU58841 combined with finasteride or dutasteride is more effective than RU58841 alone for hair loss. Users suggest combining these with minoxidil and microneedling for better results.

      community Longterm ru58841 users + my experience

      in Treatment  8 upvotes 1 week ago
      RU58841 users report mixed results, with some experiencing no benefits and others noting regrowth but potential side effects. Many prefer finasteride and minoxidil due to better-studied safety profiles.

      community How does dutasteride regrowth work?

      in Finasteride/Dutasteride  6 upvotes 4 months ago
      A 25-year-old man with hair loss from bleach damage is using oral minoxidil and considering adding Dutasteride for better regrowth and prevention. He seeks advice on Dutasteride's effectiveness and potential benefits over finasteride, and is also curious about RU58841.

      community 15 years of finasteride/minoxidil

      in Update  194 upvotes 5 months ago
      A user shared a 15-year experience using minoxidil and finasteride for hair loss, stating that despite never missing a dose, their hairline continued to recede slowly. Other users suggested that the hair loss might be exacerbated by the use of steroids and recommended considering other treatments like dutasteride and RU58841.

      community If RU58841 is such an effective anti androgen

      in Research/Science  46 upvotes 8 months ago
      RU58841 is discussed as a topical anti-androgen for hair loss, but its effectiveness and safety are not well-documented, leading to mixed opinions and experiences among users. Some combine it with finasteride, but concerns about side effects and lack of FDA approval limit its popularity.

      community Update: 4 Month progress on Fin/Min plus dermaroller

      in Progress Pictures  559 upvotes 9 months ago
      A user shared a 4-month update on their hair regrowth progress using finasteride, minoxidil, a dermaroller, ketoconazole shampoo, multivitamins, and biotin, and received positive reactions and inquiries from others. They also mentioned lifestyle changes such as quitting creatine, alcohol, and smoking, which may have contributed to their success.

      community Hair much worse after 6 months?

      in Progress Pictures  230 upvotes 11 months ago
      A user experienced significant hair loss after 6 months of using 0.5mg finasteride daily. Suggestions from others included trying Dutasteride and Minoxidil, getting professional help from a dermatologist, and addressing high iron levels that could be contributing to the hair loss.

      community 11-month progress (fin+min +microneedling+nizoral). Am I ready for HT or should I wait more?

      in Progress Pictures  44 upvotes 1 year ago
      The user "jsonparquet" shared their 11-month progress using a combination of finasteride, minoxidil, microneedling, and Nizoral for hair loss. Other users expressed amazement and suggested waiting another year before considering a hair transplant. One user shared their own experience of slow but steady gains over 3 years using a regimen of topical finasteride and minoxidil.
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