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Pioglitazone usually doesn't effectively treat or cure lichen planopilaris.

Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.

Sebaceous glands play a key role in skin health, immunity, and various skin diseases.

The cause of Frontal fibrosing alopecia, a type of hair loss, is complex, likely involving immune responses and genetics, but is not fully understood.

PPAR agonists show promise for skin conditions but need more research before being a main treatment.

Blocking EGFR in skin cells doesn't majorly increase inflammation markers.

PPAR alpha may help in hair growth and could be a target for treatment.

PPAR-γ helps control skin oil glands and inflammation, and its disruption can cause hair loss diseases.

TGFβ signaling prevents sebaceous gland cells from producing fats.

Prostaglandins and the enzyme AKR1C3 could play a role in skin cancer and hair loss, and further research is needed to understand these mechanisms.

Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.

Pig skin cells can turn into mesodermal cells but lose their ability to become neural cells.

CRAC channels are crucial for the development and function of specialized immune cells, preventing severe inflammation and autoimmune diseases.

TCDD speeds up skin barrier formation by increasing certain gene expressions.

The conclusion is that androgenetic alopecia and senescent alopecia have unique gene changes, suggesting different causes and potential treatments for these hair loss types.

The document concludes that PCOS has a strong genetic component, but more research is needed to fully understand the specific genes involved.

Sebaceous glands can heal and regenerate after injury using their own stem cells and help from hair follicle cells.

Understanding how androgens and their receptors work can lead to improved treatments for skin diseases.

Lysophospholipids like LPA and S1P are important for hair growth, immune responses, and vascular development, and could be targeted for treating diseases.

The new anti-acne treatment HA-P5 effectively reduces acne by targeting two key receptors and avoids an enzyme that can hinder treatment.

NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.

Blocking Wnt/β-catenin signaling with EGF receptor is necessary for proper hair growth.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

Vitamin D receptor interacts with certain dietary components to help prevent diseases and regulate hair growth.

Overexpressing the mineralocorticoid receptor in mouse skin causes skin thinning, early skin barrier development, eye issues, and hair loss.

LPA3 is crucial for embryo implantation and links LPA to prostaglandin signaling.

PGD2 increases androgen receptor activity in hair cells, which could be targeted to treat hair loss.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Hormonal treatment is effective for women with acne not helped by usual treatments, especially if they have hormonal imbalances.

All-trans retinoic acid at high doses harms goat hair growth cells and could be bad for hair growth.