9 citations
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April 2018 in “Canadian Journal of Animal Science” This study found that LEF-1 expression influences dermal papilla cells' proliferation through Wnt signaling, impacting the potential for cashmere yield improvement.
3 citations
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December 2024 in “Journal of Animal Physiology and Animal Nutrition” In this study, researchers found that reducing FGF20 expression in dermal papilla cells of fine-wool sheep impedes the growth and differentiation of hair follicle stem cells, providing insights into wool trait improvement and regenerative medicine applications.
December 2023 in “Animals” In this study, researchers analyzed miRNA and gene expression in the hair follicles of FMD during different hair cycle stages, identifying differential expression patterns and key pathways involved in hair follicle development and growth.
1 citations
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February 2016 in “Cell Transplantation” In this study, researchers found that hair follicles and dermal fibroblasts, including dermal papilla cells, supported sustained hair growth in transplanted murine models, with RNA-seq analysis revealing active signaling pathways and gene expression patterns.
333 citations
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March 2000 in “Proceedings of the National Academy of Sciences” In this study, researchers established that increased expression of the human GLI-1 gene in mouse skin leads to the development of tumors that closely resemble human basal cell carcinomas, without requiring additional mutations in the p53 or Ha ras genes.
35 citations
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February 2019 in “Cell Communication and Signaling” This study found that BMP6 and Wnt10b competitively regulate the transition between hair follicle growth phases, offering new insights into hair follicle cycling and potential hair loss treatments.
5 citations
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February 2023 in “Genes” In this study, researchers found that specific miRNAs may regulate cashmere fiber traits in goats by targeting genes related to hair follicle activities, with significant expression differences between breeds.
June 2025 in “Biomolecules” In this study, researchers found that activating RORA in hair follicle stem cells reduced the expression of cytoskeleton-related genes, affecting cell migration and adhesion, which may aid in understanding hair follicle development and potentially inform alopecia treatments.
March 2025 in “International Journal of Molecular Sciences” This review explores melatonin's role in hair follicle cycles and its molecular mechanisms that enhance antioxidant capacity and modulate gene expression, offering potential strategies to improve cashmere production and treating human alopecia, according to the authors.
November 2005 in “Nature Reviews Molecular Cell Biology” In this study, researchers discovered that the interaction between the hairless protein and the wise protein is crucial for hair-follicle regeneration, helping bald mice regrow fur.
October 2005 in “Nature reviews. Molecular cell biology (Print)” This study suggests that the interaction between the hairless and wise proteins can help bald mice regrow fur, highlighting its essential role in hair-follicle regeneration.
13 citations
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January 2018 in “Cellular Physiology and Biochemistry” This study found that UVB irradiation alters skin stem cell niches leading to signs of photoaging, which may be reversed by adipose-derived stem cells through BMP4 pathway modulation and niche remodeling.
338 citations
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July 2009 in “Development” This study demonstrates that Sox2-positive dermal papilla cells specify particular hair follicle types by showing heterogeneity in gene expression and pathway activation in these cells.
103 citations
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March 2011 in “PLoS Biology” This study found that a mutation in the BMP12/GDF7 gene is associated with the Naked neck trait in chickens, reducing neck feathering due to altered signaling pathways.
14 citations
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April 2022 in “Functional & Integrative Genomics” This study identified specific miRNAs and mRNAs involved in the development of secondary hair follicles in cashmere goats, particularly noting a targeted relationship between chi-miR-30e-5p and DLL4.
2 citations
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April 2022 in “Genes” This study identifies a polygenic basis for atypical recurrent flank alopecia in Cesky Fousek dogs through genome-wide association analysis and gene expression profiling, highlighting several metabolic pathways involved in the condition.
1 citations
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February 2023 in “International Journal of Molecular Sciences” This study found that exogenous melatonin improved cashmere fiber quality and yield in goats by enhancing antioxidant capacity and reducing pro-aging cytokine expression in secondary hair follicles.
January 2026 in “International Journal of Research and Innovation in Applied Science” This case report details a rare instance of malignant proliferating trichilemmal tumour in a 60-year-old male, emphasizing the significance of histochemical and immunohistochemical markers for accurate diagnosis and differentiation from squamous cell carcinoma.
The researchers reported that PPARβ/δ may influence the yak hair follicle cycle by modulating lipid metabolism in dermal papilla cells, with varying expression during different hair growth phases, affecting both lipid content and cell proliferation.
This study found that recombinant human type XVII collagen (rhCOL17A1) promotes hair growth by activating the Wnt/β-catenin and SHH/GLI signaling pathways and increasing type XVII collagen expression, with significant effects observed in both cell and mouse models.
January 2025 in “Biochimica et Biophysica Acta (BBA) - Molecular Cell Research” This study found that EGCG, a compound from green tea, may enhance the proliferation and antioxidant activity of dermal papilla cells by upregulating VEGFA expression, potentially aiding hair follicle growth.
April 2023 in “Pharmacognosy Magazine” In a study using a mouse model, Cerasus serrulata flower extracts significantly increased β-catenin and VEGF expression, promoting hair blackening and suggesting potential as a treatment for premature greying.
July 2014 in “American Journal of Clinical Dermatology” The editorial concludes that while evidence-based medicine is crucial, doctors should also use their own experience and consider patient preferences in dermatology care.
In this study, researchers used transcriptome sequencing to identify 1543 differentially expressed genes between cashmere and normal goats, implicating several signaling pathways and key regulators in the distinct gene expression profiles linked to cashmere fiber production, which advances understanding of cashmere goat genetics.
149 citations
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July 2017 in “PLoS Biology” This study found that hair follicle patterning in development may arise from a combination of epidermal prepattern signals and mesenchymal self-organisation, with fibroblast growth factor and bone morphogenetic protein activities playing key roles.
92 citations
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August 2017 in “Proceedings of the National Academy of Sciences of the United States of America” This study found that newborn mouse skin organoids can robustly grow hair in vivo, while adult organoids require specific interventions to restore their hair-forming ability.
44 citations
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December 1991 in “Annals of the New York Academy of Sciences” This study observed that epidermal growth factor and fibroblast growth factor have distinct roles in sheep skin, with EGF involved in differentiation and FGF in bulb proliferation and fiber growth.
26 citations
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January 2016 in “Annals of Dermatology” This study found that Ecklonia cava polyphenols increased human dermal papilla cell proliferation and extended hair shaft length in vitro and ex vivo, suggesting potential as a therapeutic candidate for hair loss.
10 citations
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June 2021 in “EMBO reports” This study found that in skin blister healing, hair follicle development is compromised as stem cells repair wounds at the expense of morphogenesis gene expression.
9 citations
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April 2023 in “Journal for Research in Applied Sciences and Biotechnology” This narrative discusses the critical roles of zinc in both biological processes and industrial applications but provides no new research findings.