Epigallocatechin-3-Gallate Promotes Dermal Papilla Cell Proliferation and Migration Through VEGFA Induction

    January 2025 in “ Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ”
    Yongqi Yu, Bohao Zhao, Jiali Li … Xinsheng Wu
    Studysummary This study found that EGCG, a compound from green tea, may enhance the proliferation and antioxidant activity of dermal papilla cells by upregulating VEGFA expression, potentially aiding hair follicle growth.
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    Research cited in this study 15

    1. Oxidative Stress in Hair Follicle Development and Hair Growth: Signaling Pathways, Intervening Mechanisms and Potential of Natural Antioxidants Journal of Cellular and Molecular Medicine · 2024
    2. Protective Activity Against Oxidative Stress in Dermal Papillae With Extracted Herbal Essential Oils Applied sciences · 2023
    3. Single-Cell Transcriptomics Reveals the Natural Product Shi-Bi-Man Promotes Hair Regeneration by Activating the FGF Pathway in Dermal Papilla Cells Phytomedicine · 2022
    4. Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022
    5. Formulation and Evaluation of Water Fraction Hair Tonic Containing Flavonoids from Ethanolic Extract of Green Tea Leaves (Camellia Sinensis L.) Majalah Obat Tradisional · 2021
    6. Applications of Tea (Camellia Sinensis) and Its Active Constituents in Cosmetics Molecules · 2019
    7. Epigallocatechin-3-Gallate Promotes the Growth of Mink Hair Follicles Through Sonic Hedgehog and Protein Kinase B Signaling Pathways Frontiers in pharmacology · 2018
    8. Hair Growth-Promoting Effect of Geranium Sibiricum Extract in Human Dermal Papilla Cells and C57BL/6 Mice BMC Complementary and Alternative Medicine · 2017
    9. Epigallocatechin Gallate-Mediated Alteration of the MicroRNA Expression Profile in 5α-Dihydrotestosterone-Treated Human Dermal Papilla Cells Annals of Dermatology · 2016
    10. Oxidative Stress-Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia Journal of Investigative Dermatology · 2015
    11. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    12. Human Hair Growth Enhancement In Vitro By Green Tea Epigallocatechin-3-Gallate (EGCG) Phytomedicine · 2006
    13. BMP Signaling in the Control of Skin Development and Hair Follicle Growth Differentiation · 2004
    14. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    15. Differences in Hair Follicle Dermal Papilla Volume Are Due to Extracellular Matrix Volume and Cell Number: Implications for the Control of Hair Follicle Size and Androgen Responses Journal of Investigative Dermatology · 1999

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