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This study found that excipients significantly influence the effectiveness of curcumin nanocrystals in dermal applications, enhancing or hindering hair follicle targeting and passive diffusion based on their selection.

This study found that microencapsulation combined with iontophoresis can significantly enhance the delivery of minoxidil sulphate to hair follicles, suggesting a synergetic approach for topical drug targeting.

This chapter discusses photodynamic therapy and its potential applications beyond cancer treatment, including conditions like alopecia and angina, but reports no new clinical findings.

This study found that curcumin nanocrystals efficiently penetrated hair follicles down to the lower infundibulum in an ex-vivo pig ear model, regardless of the gel vehicle used, though passive dermal penetration varied with the vehicle’s skin hydrating properties.

This study found that NIMP-R14-conjugated nanoparticles, loaded with roflumilast, effectively targeted neutrophils to reduce inflammation and improve symptoms in a mouse model of psoriasiform dermatitis, suggesting potential for targeted therapy in autoimmune skin diseases.

This study found that combining laser ablation with nanoparticulate drug formulations effectively enhanced the skin and follicular delivery of hydrophilic drugs like minoxidil and minocycline in preclinical models.

This study concluded that chitosan nanoparticles loaded with minoxidil effectively target hair follicles and reduce dermal exposure compared to iontophoresis, despite similar drug delivery potential to the follicles.

This study found that nanostructured lipid carriers with clobetasol propionate significantly enhance follicular drug delivery compared to commercial cream, and manual massage further doubles follicular retention.

This study developed polymer nanoparticles with and without chitosan coating to deliver dutasteride to hair follicles for treating androgenic alopecia. Both nanoparticle types showed controlled drug release and enhanced follicle targeting, especially with mechanical stimulus, supporting their potential as effective topical carriers in skin layers.

This review summarized advancements in intestinal lymphatic drug delivery, emphasizing the evolving understanding of lymphatics as active players in health and disease, which has led to innovative therapeutic strategies and enhanced pharmacokinetic outcomes via this delivery route.

This review discusses nanoparticle systems for cancer treatment and reports no new clinical results; the authors emphasize their potential to reduce systemic toxicity and call for further development.

Dr. Jia-You Fang is a highly experienced researcher in drug delivery and related fields, with numerous publications and international collaborations.

This study demonstrates that massage significantly enhances the follicular targeting of dutasteride-loaded nanocapsules, increasing drug accumulation in hair follicles by up to 5 times.

Nanoparticles can be used to deliver drugs to hair follicles, potentially improving treatments for conditions like acne and alopecia, and could also be used for vaccine delivery and gene therapy.

This study explores potential strategies for targeted drug delivery specifically to pancreatic beta-cells in type 2 diabetes treatment, highlighting methods for inducing drug expression in beta-cells, suitable drug carriers, active targeting peptides, and optimal administration routes.

This study explored the complex roles of niche cells in regulating hair follicle stem cells, identifying specific cell functions such as signaling, sensing, and relaying messages, which could provide insights into treating hair loss conditions like androgenetic alopecia and alopecia areata.

This study explores the potential of platelet-rich plasma (PRP) as a novel adjuvant therapy for eczema, positing that it may alleviate inflammation, enhance skin barrier function, and reduce recurrence.

This study found that lipid nanocarriers called squarticles, conjugated with an antibody, enhanced minoxidil uptake in dermal papilla cells, potentially improving alopecia treatments.

In this study, peptide-based nanoparticles were successfully used to deliver the CRISPR-Cas9 system into cancer cells, effectively targeting and editing KRAS mutations, suggesting promising therapeutic potential for cancer treatment.

This review highlights novel drug delivery systems for alopecia that enhance localization in the pilosebaceous unit, reduce systemic exposure, and support sustained drug release, with a focus on optimized follicular carriers ranging from 100-300 nm for improved drug residence compared to conventional methods.

This study found that niosomes significantly enhanced the skin deposition of retinoic acid while reducing its permeation, outperforming other tested nanoformulations.

This review examines the role of hair follicles and sebaceous glands in percutaneous drug delivery but does not report new clinical results; it calls for further exploration of follicle-targeting therapies.

This review discusses the development and clinical progression of PROTAC technology for targeted protein degradation, highlighting its potential to address previously "undruggable" targets but reports no new clinical results.

This review highlights the potential of PROTACs to transform cancer treatment by selectively degrading oncogenic proteins, overcoming drug resistance, and reducing toxicity; it also discusses challenges in optimizing these therapies for personalized applications.

This review highlights that direct drug delivery to the lungs for treating lung cancer may offer more precise targeting while reducing side effects compared to traditional methods.

This study found that nanobubble-encapsulated diclofenac with ultrasound-targeted microbubble destruction (DNBs-UTMD) can enhance the anti-tumor efficacy of Doxil® by regulating the tumor immune microenvironment, improving drug uptake, and increasing T cell responses while reducing immune-suppressive cells in the process.

This review discusses the potential for surface-modified nanostructured lipid carriers to enhance hair regrowth by improving drug absorption and stability, focusing on their use with agents like minoxidil and finasteride for hair loss treatment.

This study found that a cholesterol-conjugated, cell-penetrating asiRNA targeting the androgen receptor effectively reduced hair loss and promoted hair growth in mouse models of androgenetic alopecia, suggesting potential as a novel treatment.

This study found that intradermal injection of a specially designed RNA molecule, cp-asiAR, successfully reduced androgen receptor levels and promoted hair growth in a mouse model of androgenetic alopecia, while also improving hair follicle characteristics in ex vivo human scalp tissues without significant toxicity.

This study found that intradermal injection of a cell-penetrating, AR-targeting asiRNA promoted hair growth and reduced androgen receptor expression in mouse models of androgenetic alopecia, suggesting its therapeutic potential.