Recent Developments in Luteolin-Loaded Nanoformulations for Enhanced Anti-Carcinogenic Activities: Insights from In Vitro and In Vivo Studies

The review highlights the potential of luteolin, a flavonoid with anti-cancer properties, and the challenges of its poor bioavailability and solubility. Recent advancements in nanoformulations, such as polymeric nanoparticles, micelles, and liposomes, have significantly improved luteolin's solubility, bioavailability, and targeted delivery, enhancing its therapeutic efficacy against cancer. In vitro and in vivo studies demonstrate that these nanoformulations increase luteolin's cytotoxicity, reduce tumor growth, and improve pharmacokinetics, particularly in cancers like breast, colorectal, and glioblastoma. These findings suggest that nanoformulations could play a crucial role in enhancing luteolin's potential as a cancer treatment.