Nanoparticle Systems Reduce Systemic Toxicity in Cancer Treatment

The document discussed the potential of nanoparticle systems to revolutionize cancer treatment by reducing systemic toxicity. Traditional chemotherapy often caused significant side effects due to its nonselective nature, affecting both cancerous and healthy cells. Nanoparticle systems, through passive and active targeting, aimed to deliver drugs specifically to tumors, minimizing damage to healthy tissues. Passive targeting utilized the enhanced permeability and retention (EPR) effect, while active targeting involved surface modifications to direct nanoparticles to tumor cells. Additionally, stimuli-responsive nanoparticles and combination therapies were explored to further enhance treatment efficacy and reduce toxicity. Despite advancements, the need for smarter nanoparticles with higher targeting specificity and drug loading capacity remained crucial for future developments.