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    Glossary Papillary Fibroblasts

    specialized skin cells aiding in structure and hair growth

    Papillary fibroblasts are specialized cells found in the upper layer of the dermis, known as the papillary dermis. These cells play a crucial role in producing and organizing the extracellular matrix, which provides structural support to the skin. They are also involved in wound healing and hair follicle development, making them essential for maintaining healthy skin and hair growth.

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    1. Lineage Identity and Location within the Dermis Determine the Function of Papillary and Reticular Fibroblasts in Human Skin Journal of Investigative Dermatology · 2018 · 159 citations
    2. Hedgehog Signaling in Papillary Fibroblasts Is Essential for Hair Follicle Regeneration during Wound Healing Journal of Investigative Dermatology · 2021 · 5 citations
    3. Dermal Hedgehog Signaling in Papillary Fibroblasts: An Emerging Key Player in Skin Regeneration Journal of Investigative Dermatology · 2022 · 2 citations
    4. Effect of Marine-Derived Saccharides on Human Skin Fibroblasts and Dermal Papilla Cells Marine Drugs · 2023 · 2 citations
    5. Mechanical Stretching Can Modify the Papillary Dermis Pattern and Papillary Fibroblast Characteristics during Skin Regeneration Journal of Investigative Dermatology · 2022 · 19 citations
    6. Expression Profiles of Tyrosine Kinases in Cultured Follicular Papilla Cells Versus Dermal Fibroblasts Journal of Investigative Dermatology · 2004 · 11 citations
    7. Induction of dermal fibroblasts into dermal papilla cell-like cells in hydrogel microcapsules for enhanced hair follicle regeneration Applied Materials Today · 2020 · 4 citations
    8. Primary cell culture and morphological characterization of canine dermal papilla cells and dermal fibroblasts Veterinary Dermatology · 2002 · 32 citations
    9. Activation of Fibroblast and Papilla Cells by Glycolipid Biosurfactants, Mannosylerythritol Lipids. Journal of oleo science · 2010 · 29 citations
    10. Effects of epidermal growth factor, fibroblast growth factor, minoxidil and hydrocortisone on growth kinetics in human hair bulb papilla cells and root sheath fibroblasts cultured in vitro Archives of Dermatological Research · 1987 · 58 citations
    11. Direct Reprograming of Mouse Fibroblasts into Dermal Papilla Cells via Small Molecules International Journal of Molecular Sciences · 2022 · 3 citations
    12. 773 Generation of human hair follicle organoids in vitro and ex vivo by co-culture of primary human hair matrix keratinocytes and dermal papilla fibroblasts Journal of Investigative Dermatology · 2020
    13. 613 Assessment of the induction and morphogenic potential of human hair matrix cells and dermal papilla fibroblasts ex vivo Journal of Investigative Dermatology · 2019 · 1 citations
    14. Engineering Spatially Organized Hair Peg-like Structures in Human Skin Constructs Using Keratinocyte–Dermal Papilla Fibroblast Spheroids and Micropatterned Dermal Scaffolds Acta Biomaterialia · 2026
    15. Hair Strengthening Evaluation of Anisotropic Osmolite Solutions (Inositol + Arginine): Cross-Talk between Dermal Papilla Fibroblast and Keratinocytes of the Outer Root Sheath Using a µHair Follicle 3D Model Cosmetics · 2018
    16. Keratinocytes maintain compartmentalization between dermal papilla and fibroblasts in 3D heterotypic tri‐cultures Cell Proliferation · 2019 · 16 citations
    17. Human Scalp Dermal Papilla and Fibrous Sheath Cells have a different expression profile of Matrix Metalloproteinases in vitro when compared to Scalp Dermal Fibroblasts Archives of Dermatological Research · 2005 · 9 citations
    18. Comparative secretome analysis of human follicular dermal papilla cells and fibroblasts using shotgun proteomics BMB Reports · 2012 · 44 citations
    19. Adenosine Stimulates Fibroblast Growth Factor-7 Gene Expression Via Adenosine A2b Receptor Signaling in Dermal Papilla Cells 2007 · 66 citations
    20. Extracellular Vesicles from Activated Dermal Fibroblasts Stimulate Hair Follicle Growth Through Dermal Papilla-Secreted Norrin Stem cells · 2019 · 37 citations
    21. Chemically induced transformation of human dermal fibroblasts to hair‐inducing dermal papilla‐like cells Cell Proliferation · 2019 · 8 citations
    22. Effects of testosterone, dihydrotestosterone and estradiol on the growth behavior of cultured hair bulb papilla cells and root sheath fibroblasts 1989 · 5 citations
    23. Engineered Nanovesicles from Fibroblasts Modulate Dermal Papillae Cells In Vitro and Promote Human Hair Follicle Growth Ex Vivo Cells · 2022 · 4 citations
    24. Effect of Fibroblast Growth Factor 10 and an Interacting Non-Coding RNA on Secondary Hair Follicle Dermal Papilla Cells in Cashmere Goats’ Follicle Development Assessed by Whole-Transcriptome Sequencing Technology Animals · 2023 · 2 citations
    25. Direct reprogramming of human fibroblasts into hair-inducing dermal papilla cell-like cells by a single small molecule Biochemical Pharmacology · 2025
    26. Fibroblast growth factor 5-short (FGF5s) inhibits the activity of FGF5 in primary and secondary hair follicle dermal papilla cells of cashmere goats Gene · 2015 · 42 citations
    27. Adenosine stimulates growth of dermal papilla and lengthens the anagen phase by increasing the cysteine level via fibroblast growth factors 2 and 7 in an organ culture of mouse vibrissae hair follicles International Journal of Molecular Medicine · 2011 · 28 citations
    28. Murine skin-derived multipotent papillary dermal fibroblast progenitors show germline potential in vitro Stem Cell Research & Therapy · 2023 · 4 citations
    29. Hair-follicle dermal papilla and sheath fibroblasts provide a supportive microenvironment for human skin regeneration 2017 · 3 citations
    30. Human hair follicle dermal papilla cell, dermal sheath cell and interstitial dermal fibroblast characteristics. PubMed · 1996 · 36 citations