Mapping the Establishment of Fibroblast Heterogeneity During Skin Development and Wound Repair

This review discusses the heterogeneity of dermal fibroblasts in healthy mouse and human skin and reports no clinical results; the authors highlight potential insights into physiological and pathological wound healing.

This study found that skin fibroblasts in mice arise from two distinct lineages which contribute differently to dermal structure and repair, impacting hair follicle formation during wound healing.

In this study, researchers analyzing human fetal skin fibroblasts found eight distinct populations with developmental stage-specific abundance, identifying markers linked to fibroblast functions in blood vessel development, dermal layers, and hair follicle maturation.

This review discusses the origins, differentiation, and function of dermal fibroblasts in skin development and healing, reporting no new clinical results.

This study suggests that human skin contains distinct fibroblast subsets with unique expression profiles and functions, which can be isolated to investigate their role in skin pathogenesis.