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This review discusses the potential of polydeoxyribonucleotide (PDRN) for various dermatological treatments and highlights its significant effects on wound healing, anti-aging, acne scars, and hair loss, but emphasizes the need for further clinical studies.

In this study, classic PDRN (50-1,500 kDa) was observed to improve wound healing quality in a mouse model by enhancing collagen composition and cell migration.

Smart microneedles improve hair loss treatment by delivering drugs precisely with fewer side effects.

This study explored a computer simulation method for selecting emulsion compositions in dermatology, finding that the PS biocomplex can be effectively used as an emulsifier or co-emulsifier, which streamlines the development process and reduces experimental demands.

This laboratory study concluded that TRPA1 and TRPV1 channels do not play a role in mechanotransduction processes in slowly adapting type II mechanoreceptors in isolated rat sinus hair follicles.

This article reviews non-surgical hair loss treatments and procedures, highlighting options like minoxidil, DHT inhibitors, and laser light therapy, and reports no new clinical findings.

In this study, microneedle-assisted delivery of polyglutamate significantly improved hair parameters, scalp symptoms, and quality of life in androgenetic alopecia patients, with no serious adverse reactions reported.

In this case report, microneedling combined with PRP improved hair density and thickness in a 40-year-old man with androgenic alopecia, without side effects, suggesting it as a therapeutic option for those avoiding long-term pharmacotherapy.

This study explored the molecular mechanisms by which Polygonum multiflorum may treat androgenic alopecia, suggesting it influences cell apoptosis and inflammation through specific pathways, with potential application value pending further testing.

This review discusses recent advances in polydopamine-based biomaterials and their growing potential in personalized medicine, but reports no new experimental results; the authors highlight both opportunities and challenges for future applications.

In this paper, three APS patients were followed over time, showing that the diagnosis and course of autoimmune polyglandular syndrome can evolve, highlighting the need for careful monitoring and potential re-evaluation.

This study found that in patients with elevated fibrinogen levels undergoing revision rhinoplasty, PDRN decreased M1 cytokines and increased M2 cytokines, potentially offering a new therapeutic approach, but further research is needed to understand its mechanisms and effects fully.

This study concluded that macrophage iron retention due to Ferroportin inactivation hinders skin wound healing but does not affect liver damage or fibrogenesis in a mouse model.

This study found that cPPARγ and dnPPARγ isoforms are differentially expressed in healthy human skin, suggesting that PPARγ modulators may have compartment-specific effects depending on isoform presence.

This study reports that patients with specific MFN2 mutations, including p.Arg707Trp, exhibit significant upper body fat overgrowth with suppressed leptin production, suggesting tissue-selective mitochondrial dysfunction and potential therapeutic targets.

This study found that onychomatricoma can fully mimic the nail unit and differentiate toward the nail bed and isthmus, distinguishing it from other pilar tumors.

This study found that both microneedling and microneedling with platelet-rich plasma improved hair thickness and density in male pattern alopecia, but no additional benefit was observed with the addition of platelet-rich plasma.

This study found that many alopecia patients misunderstood the usage and side effects of topical minoxidil, especially those who had not consulted a doctor.

This study found that TRPA1-deficient mice exhibited normal cold sensitivity but had decreased mechanical response in nociceptors, suggesting TRPA1's role in mechanotransduction.

This case study reports that a 26-year-old woman with epidermolysis bullosa prurogompsa also presented with unique findings of co-existing muscular dystrophy and immune-based myasthenia gravis, with significant improvement following steroid treatment.

This study found that substance P and calcitonin-gene-related peptide have different roles in regulating hair growth in mice, with substance P promoting anagen progression and calcitonin-gene-related peptide inhibiting it.

This chapter discusses photodynamic therapy and its potential applications beyond cancer treatment, including conditions like alopecia and angina, but reports no new clinical findings.

This study suggests that five small molecules can induce hair follicle neural crest stem cells to differentiate toward motor neuron progenitor cells with a unipotent differentiation potential.

This study found that the film-trigger applicator system enhanced drug delivery efficiency and skin penetration of dissolving microneedles compared to traditional patch systems in both lab and animal models.

This study reviewed the challenges of delivering nucleic acids for gene therapy, highlighting the limitations of non-viral vehicles and exploring bioinspired strategies using cell membrane camouflage for improved delivery efficacy.

This study suggests that paeoniflorin's protective effects on brain astrocytes may be mediated by TSPO and neurosteroids biosynthesis.

In this study, severe hair loss occurred in PKC epsilon transgenic mice treated with DFMO during skin tumor prevention, highlighting a link between polyamine biosynthesis, hair follicle maintenance, and metastasis suppression.

This study observed that POMP is strongly expressed in the root sheath hair follicles of Liaoning Cashmere goats and its expression can be regulated by certain factors, which may influence cashmere growth.

This study reports that patients with Alzheimer's disease have increased levels of polyamines in their hair.

This study investigated the use of methylene blue in a niosomal hydrogel for photodynamic treatment of acne and found that it led to significant improvement in inflammation compared to IPL treatment.