Formulation and Clinical Evaluation of Niosomal Methylene Blue for Successful Treatment of Acne

The study aimed to evaluate the use of methylene blue (MB) in niosomal hydrogel form for photodynamic treatment of acne. Researchers formulated and characterized MB niosomes, examining factors like drug amount and cholesterol: span 60 ratios. The optimal MB amount was 1000 µg, and the release followed a Higuchi diffusion mechanism. Incorporating MB niosomes into a 3% HPMC gel resulted in a feasible release rate. Clinical evaluation of the niosomal gel showed significant improvement in acne inflammation compared to IPL treatment, suggesting its potential efficacy for moderate to severe acne cases.